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| 1 | β-catenin activation in hair follicle dermal stem cells in duces ectopic hair outgrowth and skin fibrosis显示文摘Hair follicle dermal sheath(DS)harbors hair follicle dermal stem cells(hfDSCs),which can be recruited to replenish DS and dermal papilla(DP).Cultured DS cells can differentiate into various cell lineages in vitro.However,it is unclear how its plasticity is modulated in vivo.Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration.Here we report that activation ofβ-catenin in DS generates ectopic HF outgrowth(EF)by reprogramming HF epidermal cells and DS cells themselves,and endows DS cells with hair inducing ability.Epidermal homeostasis of pre-existing HFs is disrupted.Additionally,cell-autonomous progressive skin fibrosis is prominent in dermis,where the excessive fibroblasts largely originate from DS.Gene expression analysis of purified DS cells with activatedβ-catenin revealed significantly increased expression of Bmp,Fgf,and Notch ligands and administration of Bmp,Fgf,or Notch signaling inhibitor attenuates EF formation.In summary,our findings advance the current knowledge of high plasticity of DS cells and provide an insight into understanding how Wnt/β-catenin signaling controls DS cell behaviors. | Yixin Tao Qingchun Yang Lei Wang Jie Zhang Xuming Zhu Qianqian Sun Yunbin Han Qian Luo Yushu Wang Xizhi Guo Ji Wu Baojie Li Xiao Yang Lin He Gang Ma | 2019 | Journal of Molecular Cell Biology2019，11，1： | 4 |
| 2 | New Core-Expanded Naphthalene Diimides for n-Channel Organic Thin Film Transistors显示文摘膨胀核心的萘 diimides 的四个班(1a, 1b, 2a, 2b, 3 和 4 ) 那头熊不同的电子缺乏的硫 heterocycles 被设计并且综合。1a 的处理答案的薄电影, 2a, 3 和 4 作为 n 隧道在空中操作了很好有电子活动性从 106 ~ 0.14 cm2/Vs 的器官的晶体管,取决于不同结合的脊梁。薄电影微观结构研究也被执行为 1a 的薄电影理解电子活动性的变化, 2a, 3 和 4。 | Yunbin Hu Xu Zhang Xiaodi Yang Hongxiang Li Xike Gao | 2013 | Chinese Journal of Chemistry2013，31，11： | 1 |
| 3 | Directional terahertz holography with thermally active Janus metasurface显示文摘Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows. | Benwen Chen Shengxin Yang Jian Chen Jingbo Wu Ke Chen Weili Li Yihui Tan Zhaosong Wang Hongsong Qiu Kebin Fan Caihong Zhang Huabing Wang Yijun Feng Yunbin He Biaobing Jin Xinglong Wu Jian Chen Peiheng Wu | 2023 | Light(Science & Applications)2023，12，6： | 1 |
| 4 | Knowledge based engineering in complicated product design显示文摘 | LiJia Yang Yunbin WeiFayuan | 2012 | Advanced Materials Research2012，466，： | 1 |
| 5 | An ATBM warhead显示文摘 | Liu Tong Yang Yunbin | 2000 | Propellants Explosives Pyrotechnics2000，25，3： | 1 |
| 6 | Fragment Shot-Line Model for Air-Defence Warhead显示文摘 | * Liu Tong Zhang Shouqi Yang Yunbin | 2000 | Propellants Explosives Pyrotechnics2000，25，2： | 1 |
| 7 | Fragment Shot - Line Model for Air - Defence Warhead 显示文摘 | Qian Lixin Liu Tong Zhang Shouqi Yang Yunbin | 2000 | Propellants Explosives Pyrotechnics2000，25，2： | 1 |
| 8 | Experimental and Numerical Analysis of Particle Migration and Patterning Behavior in a Gravel Pack显示文摘Due to its long lifespan and high sand-removal efficiency,gravel packing is one of the most applied sand control methods during the recovery of reservoirs with sanding problems.The blockage and retention of injected sand in a gravel pack is a complex process affected by multiple mechanisms.The majority of existing studies based on the phenomenological deep bed filtration(DBF)theory focused on the gravel pack’s overall permeability damage and failed to obtain the inner-pore particle distribution pattern.In this work,experiments and simulations were carried out to reveal the particle distribution in a gravel pack during flooding.In particular,through real-time monitoring of particle migration,the penetration depth and distribution pattern of invaded particles with different gravel-sand particle ratios,fluid viscosities and injection rates could be determined.By simplifying each unit bed element(UBE)into a pore-throat structure with four tunnels(two horizontals for discharge and two verticals for sedimentation),a new network simulation method,which combines deep bed filtration with a particle trajectory model,was implemented.Cross comparison of experimental and numerical results demonstrates the validity and accuracy of the model. | Bobo Luo Yunbin Xiong Zhuoyi Li Zhanqing Qu Fenggang Liu Tiankui Guo Zugui Yang Yina Shi | 2023 | Fluid Dynamics & Materials Processing2023，19，4： | 0 |
| 9 | Selenium-containing core-expanded naphthalene diimides for high performance n-type organic semiconductors显示文摘The incorporation of heavy atoms into molecular backbone is an extremely straightforward strategy for fine-tuning the optoelectronic properties of organic semiconductors.However,it is rarely studied in n-type small molecules.Herein,by selenium substitution of NDI3 HU-DTYM2,two Se-decorated core-expanded naphthalene diimides(NDI)derivatives DTYM-NDI3 HUDSYM(1)and NDI3 HU-DSYM2(2)were synthesized.In comparison with the reference S-containing compound NDI3 HUDTYM2,the highest occupied molecular orbital(HOMO)and lowest unoccupied molecular orbital(LUMO)energy levels of 1 and 2 were fine-tuned with?HOMO of about 0.2 e V,?LUMO of 0.1 e V and the narrowed HOMO-LUMO gaps.More surprisingly,the as-spun organic thin film transistors(OTFTs)based on 1 and 2 both showedμe,satvalues as high as1.0 cm2 V-1 s-1,which are 2-fold higher than that of NDI3 HU-DTYM2 with the same device structure and measurement conditions.In addition,the single crystal OFET devices based on Se-containing compound NDI2 BO-DSYM2 showed a highμe,satvalue of 1.30 cm2 V-1 s-1.The molecular packing of NDI2 BO-DSYM2 in single crystals(two-dimensional supramolecular structure formed by intermolecular Se···Se interactions)is quite different from that of a S-containing compound NDI-DTYM2(one dimensional supramolecular structure formed by intermolecularπ-πstacking).Therefore,the Se substitution can cause dramatic change about molecular stacking model,giving rise to high n-type OTFT performance.Our results demonstrated an effective strategy of the heavy atom effect for designing novel organic semiconductors. | Wenjie Han Zhongli Wang Yunbin Hu Xiaodi Yang Congwu Ge Xike Gao | 2020 | Science China Chemistry2020，63，9： | 0 |
| 10 | 超高真空环境中两个超薄碳膜之间的距离测量显示文摘The stability of the magnetic fields is crucial for the precision experiments conducted at the experimental Cooler Storage Ring CSRe.From 2016,sudden changes of dB=B>10−4 of CSRe dipole magnetic fields happened irregularly which made the precision mass measurements at CSRe difficult to proceed.Therefore,a monitoring system have been built and the instabilities of the power supply and field strengths of the CSRe dipole magnets have been investigated in 2017. | Yan Xinliang Wu Fengjun Yang Wenjie Wang Xiaojun Zhou Yunbin Wang Meng Zhou Xu Zhang Min Gao Daqing An Shi Yuan Youjin Zhang Yuhu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 11 | Development and Application of a Multidrug-Resistant Tuberculosis Case Management System—Yunnan Province,China,2017–2020显示文摘Introduction:Treatment and case management of multidrug-resistant tuberculosis(MDR-TB)is a significant challenge in tuberculosis(TB)control and prevention.This pilot study aims to apply and test a new electronic information system in order to help bolster case management of MDR-TB.Methods:The MDR-TB Case Management System(CMS)was developed and piloted in the Yunnan Tuberculosis Clinical Center(TCC)in 2017.Next,5 sites in Yunnan were randomly selected and sampled as pilots in 2018.The real-time regular follow-up rate(RFUR)was calculated for pilot sites.Loss to follow-up(LTFU)rates of MDR-TB treatment cohorts between pilot and non-pilot sites were compared by a chi-square test.LTFU for MDR-TB treatment cohorts was then assessed by univariate and multivariate binary logistic regression.Results:The average regular follow-up rate was 90.7%in TCC and 73.7%in five other pilot sites of Yunnan Province respectively.The average LTFU rate for pilot sites(9.0%)was lower than non-pilot sites(20.6%,P<0.01).The risk of LTFU during MDR-TB treatment reduced 61.7%in CMS pilot cases(adjusted odds ratio:0.38,95%confidence interval:0.23–0.60)compared with non-pilot cases.Conclusions:As a significant supplement to the Tuberculosis Information Management System,the CMS strengthened the collection,analysis,and utilization of strategic information for MDR-TB cases.The system improved case management by embedding it as a tool of the Comprehensive Supportive Care service model. | Jinou Chen Yunzhou Ruan Kai Wang Ling Li Yunbin Yang Rui Yang Lin Xu | 2022 | China CDC weekly2022，4，38： | 0 |
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