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| 1 | The fractal measurement of experimental images of supersonic turbulent mixing layer显示文摘Flow visualization of supersonic mixing layer has been studied based on the high spatiotemporal resolution Nano-based Planar Laser Scattering(NPLS) method in SML-1 wind tunnel. The corresponding images distinctly reproduced the flow structure of laminar,transitional and turbulent region,with which the fractal measurement can be implemented. Two methods of measuring fractal dimension were introduced and compared. The fractal dimension of the transitional region and the fully developing turbulence region of supersonic mixing layer were measured based on the box-counting method. In the transitional region,the fractal dimension will increase with turbulent intensity. In the fully developing turbulent region,the fractal dimension will not vary apparently for different flow structures,which em-bodies the self-similarity of supersonic turbulence. | ZHAO YuXin YI ShiHe TIAN LiFeng HE Lin CHENG ZhongYu | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 24 |
| 2 | Aero-optical aberration measuring method based on NPLS and its application显示文摘The existing methods for measuring aero-optical aberration suffer from several problems,such as low spatiotemporal resolution,sensitivity to environment,and integral effects.A new method for measuring aero-optical aberration of supersonic flow is proposed.Based on the self-developed measuring method of supersonic density field,the wavefront aberration induced by a cross-section of supersonic flow field could be measured by ray-tracing.Compared with other methods,the present one has three significant innovations:(1) high spatiotemporal resolution.Its time resolution is 6 ns,and the spatial resolution can reach up to micrometers;(2) it can avoid the integral effects and study the wavefront aberration induced by the flow field of interest locally;(3) it can also avoid the influence from the test section wall boundary layers and environmental disturbances.The present method was applied to supersonic flow around an optical bow cap.The results of high spatiotemporal resolution reveal fine wavefront structures,and show that shock waves,expansion waves and turbulent boundary layers have different impacts on the wavefront aberration. | YI ShiHe TIAN LiFeng ZHAO YuXin HE Lin CHEN Zhi | 2010 | Chinese Science Bulletin2010，55，31： | 20 |
| 3 | Visualization of coherent structures in a supersonic flat-plate boundary layer显示文摘Flow in a flat-plate zero-pressure-gradient boundary layer at Mach 3 was visualized via nanoparticle-based planar laser scattering (NPLS). Coherent structures such as an individual hairpin vortex and hairpin packet were identified in the streamwise-wall-normal plane on the basis of the now accepted hairpin model. Λ-shaped vortices were found in a staggered pattern in the stream-wise-spanwise plane, which indicated H-type transition in the present experiments. This is the direct evidence (in the form of flow visualization) of such coherent structures in a supersonic boundary layer. A series of NPLS images taken in streamwise-spanwise planes at different heights is presented, and the three-dimensional structures of the supersonic boundary layer agree well with the hairpin model. | HE Lin YI ShiHe ZHAO YuXin TIAN LiFeng CHEN Zhi | 2011 | Chinese Science Bulletin2011，56，6： | 19 |
| 4 | The experimental study of interaction between shock wave and turbulence显示文摘The interaction between shock wave and turbulence has been studied in supersonic turbulent mix layer wind tunnel. The interaction between oblique shock wave and turbulent boundary layer and the influence of large vortex in mix layer on oblique shock wave have been observed by NPLS technique. From NPLS image, not only complex flow structure is observed but also time-dependent supersonic flow visualization is realized. The mechanism of interaction between shock wave and turbulence is discussed based on high quality NPLS image. | ZHAO YuXin YI ShiHe HE Lin CHENG ZhongYu TIAN LiFeng | 2007 | Chinese Science Bulletin2007，52，10： | 18 |
| 5 | Study of density field measurement based on NPLS technique in supersonic flow显示文摘Due to the influence of shock wave and turbulence, supersonic density field exhibits strongly inhomogeneous and unsteady characteristics. Applying traditional density field measurement techniques to supersonic flows yields three problems: low spatiotemporal resolution, limitation of measuring 3D density field, and low signal to noise ratio (SNR). A new method based on Nano-based Planar Laser Scattering (NPLS) technique is proposed in this paper to measure supersonic density field. This method measures planar transient density field in 3D supersonic flow by calibrating the relationship between density and concentration of tracer particles, which would display the density fluctuation due to the influence of shock waves and vortexes. The application of this new method to density field measurement of supersonic optical bow cap is introduced in this paper, and the results reveal shock wave, turbulent boundary layer in the flow with the spatial resolution of 93.2 μm/pixel. By analyzing the results at interval of 5 μs, temporal evolution of density field can be observed. | TIAN LiFeng YI ShiHe ZHAO YuXin HE Lin CHENG ZhongYu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 15 |
| 6 | An experimental study of aero-optical aberration and dithering of supersonic mixing layer via BOS显示文摘The optical performance of supersonic mixing layer is heavily deteriorated by the aero-optical aberration and dithering of coherent structures, but current measuring methods limit the spatiotemporal resolution in relevant studies. A high resolution whole-field aero-optical aberration and dithering measuring method based on the Background Orient Schlieren (BOS) technique was studied. The systematic structure, sensitivity and resolution of BOS are analyzed in this paper. The aero-optical aberration and dithering of streamwise structures in supersonic mixing layers were quantificationally studied with BOS. The aberration field of spanwise structures revealed the ribbon-like aberration structures, which heavily restrict the optical performance of a mixing layer. The quantifications of aero-optical aberration and dithering are very important in studying aero-optical performance of supersonic mixing layer. | ZHAO YuXin , YI ShiHe, TIAN LiFeng, HE Lin & CHENG ZhongYu College of Aerospace and Material Engineering, National University of Defense Technology, Changsha 410073, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 13 |
| 7 | A flow control study of a supersonic mixing layer via NPLS显示文摘The flow control of a supersonic mixing layer was studied in a supersonic mixing layer wind tunnel with convective Mach number (Mc) at 0.5. The passive control of the mixing layer was achieved by perturbation tapes on the trailing edge of the splitter plate. The control effects of 2D and 3D perturbation tapes with different sizes were compared. The mixing layer was visualized via NPLS,and the transient fine structures were identifiable in NPLS images,which were used to analyze the effects of flow control. The results show that the 2D tapes can enhance the 2D characteristic of the mixing layer,delaying mixing layer transition; and the 3D tapes can enhance the 3D characteristic of the mixing layer,advancing mixing layer transition. 3D structures of the mixing layer were visualized,and the H-type Λ vortexes were found with 3D tapes control. | YI ShiHe HE Lin ZHAO YuXin TIAN LiFeng CHENG ZhongYu | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 10 |
| 8 | Aero-optical wavefront measurement technique based on BOS and its applications显示文摘A collimated light beam will be refracted if it propagates through a flow-field with index-of-refraction variations,and its wavefront will be distorted.If we measure the deflection angle of the light beam,the gradient of the wavefront can be obtained using the Malus law,and the wavefront aberration can be computed with a reconstruction algorithm.Two characteristics of background oriented schlieren(BOS) are conducive to wavefront aberration measurement:BOS can be used to measure the deflection angle of a light beam by measuring the displacement field between the reference image and the experiment image.Moreover,in a BOS system of Schlieren mode,only the ray perpendicular to the background image can be captured with a camera.This is helpful to measure wavefront aberrations that occur after a planar wavefront has passed through the flow-field.Based on these characteristics of BOS of Schlieren mode,a new wavefront measurement technique,which is called the BOS-based wavefront technique(BOS-WT),is proposed in this paper.It works by constructing the relationship between the displacement of the background image and the aero-optical wavefront gradient and uses the Southwell wavefront reconstruction algorithm.A BOS-WT system was assembled,and its temporal resolution was found to be 6 ns,and its temporal-correlation resolution reached 0.2 μs.A BOS-WT can measure the time-correlation transient wavefront quantitatively.It is simple and easy to operate.In this paper,we also present a study of the aero-optical performance of supersonic mixing layer based on our BOS-WT transient wavefronts at an interval of 5 μs.The results showed the wavefront was transient and distorted after it had passed through the mixing layer.Through the analysis of the data at the 5 μs interval,the temporal evolution of wavefront can be obtained. | TIAN LiFeng YI ShiHe ZHAO YuXin HE Lin CHEN Zhi | 2011 | Chinese Science Bulletin2011，56，22： | 10 |
| 9 | Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis显示文摘Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To slow or reverse its progression, inflammation should be inhibited, and chondrocyte proliferation should be promoted. Tetrahedral framework nucleic acids can be internalized by chondrocytes(even inflammatory chondrocytes) and can enhance their proliferation and migration. Wogonin, a naturally occurring flavonoid,suppresses oxidative stress and inhibits inflammation. In this study, tetrahedral framework nucleic acids were successfully selfassembled and used to load wogonin. We confirmed the effective formation of tetrahedral framework nucleic acid/wogonin complexes by dynamic light scattering, zeta potential analysis, transmission electron microscopy, and fluorescence spectrophotometry. Tetrahedral framework nucleic acids, wogonin, and especially tetrahedral framework nucleic acid/wogonin complexes effectively alleviated inflammation in vitro and in vivo and prevented cartilage destruction. In addition, these materials remarkably downregulated the expression of inflammatory mediators and matrix metalloproteinases, upregulated chondrogenic markers, and promoted tissue inhibitor of metalloproteinase 1 and B-cell lymphoma 2 expression. In vivo, after treatment with tetrahedral framework nucleic acid/wogonin complexes, the bone mineral density in regenerated tissues was much higher than that found in the untreated groups. Histologically, the complexes enhanced new tissue regeneration, significantly suppressed chondrocyte apoptosis, and promoted chondrogenic marker expression. They also inhibited cell apoptosis, increased chondrogenic marker expression, and suppressed the expression of inflammatory mediators in osteoarthritis. Therefore, we believe that tetrahedral framework nucleic acid/wogonin complexes can be used as an injectable form of therapy for osteoarthritis. | Sirong Shi Yang Chen Taoran Tian Songhang Li Shiyu Lin Yuxin Zhang Xiaoru Shao Tao Zhang Yunfeng Lin Xiaoxiao Cai | 2020 | Bone Research2020，8，1： | 9 |
| 10 | Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose显示文摘This study was conducted to examine the association of perfluoroalkyl substance(PFAS)exposure with gestational diabetes mellitus(GDM) risk and postpartum fasting blood glucose.We used a 1:2 matched case–control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1–2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum.Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/m L with a interquartile range(IQR) of 2.82–6.54 ng/m L. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio(ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat(1 m-PFOS), perfluoro-3/4-metylheptylsulfonat(3 m+4 m-PFOS), perfluoro-5-metylheptylsulfonat(5 m-PFOS), and perfluorohexane sulfonate(PFHx S) were 2.03(95% CI: 1.09–3.77), 1.93(95% CI:1.04–3.58), 2.48(95% CI: 1.33–4.65), and 2.26(95% CI: 1.21–4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism. | Yuxin Wang Lei Zhang Yue Teng Jiayu Zhang Lin Yang Jingguang Li Jianqiang Lai Yunfeng Zhao Yongning Wu | 2018 | Journal of Environmental Sciences2018，30，7： | 8 |
| 11 | Density field measurement and approximate reconstruction of supersonic mixing layer显示文摘The density field measurement of supersonic mixing layer based on the nanoparticle-based planar laser scattering method was studied.The calibration of experimental images was analyzed,and the relation between tracer particles concentration and local density of flowfield was calibrated with oblique shockwave experiment.According to the characteristic of mixing layer images,the influence of uneven light intensity distribution was calibrated.With these calibration methods,the density field of supersonic mixing layer with convective Mach number at 0.12 was measured.By analyzing the spanwise vortical structures and streamwise density field,the three dimensional(3D) density field was approximately reconstructed,which apparently reflected the 3D structure of supersonic mixing layer. | ZHAO YuXin YI ShiHe TIAN LiFeng HE Lin CHENG ZhongYu | 2010 | Chinese Science Bulletin2010，55，19： | 7 |
| 12 | Luminescent metal nanoclusters for biomedical applications显示文摘Luminescent metal nanoclusters (NCs) have recently emerged as a novel class of luminescent nanomaterials and hold significant potential in biomedicine owing to their ultrasmall (<2nm) size,excellent photostability,and good biocompatibility.The recent rapid advances in the synthesis and functionalization of luminescent metal NCs have enabled scientists to develop colorful nanomaterials and nanodevices for a wide range of biomedical applications.In this review,we summarize the characteristics and advantages of luminescence from metal NCs,and highlight their applications in biomedicine.We focus on the research in biomedical detection,bio-imaging,drug delivery,and therapy,especially for the advances in the last five years.Luminescent metal NCs display a series of unique superiorities in biomedical applications,and the recent achievements have brought a lot of benefits to the diagnosis and treatment of clinical diseases,especially for tumors and cancers.Finally,we put forward the main challenges that currently still hinder the basic science studies and the practical development of luminescent metal NCs in biomedical applications.Overall,we expect that luminescent metal NCs will play a much more important role in future biomedicine and clinical applications. | Yu Su Tiantian Xue Yuxin Liu Jinxia Qi Rongchao Jin Zhenkun Lin | 2019 | Nano Research2019，12，6： | 6 |
| 13 | Experimental study of a supersonic turbulent boundary layer using PIV显示文摘Particle image velocimetry was applied to the study of the statistical properties and the coherent structures of a flat plate turbulent boundary layer at Mach 3. The nanoparticles with a good flow-following capability in supersonic flows were adopted as the tracer particles in the present experiments. The results show that the Van Driest transformed mean velocity profile satisfies the incompressible scalings and reveals a log-law region that extends to y/ =0.4, which is further away from the wall than that in incompressible boundary layers. The Reynolds stress profiles exhibit a plateau-like region in the log-law region. The hairpin vortices in the streamwise-wall-normal plane are identified using different velocity decompositions, which are similar to the results of the flow visualization via NPLS technique. And multiple hairpin vortices are found moving at nearly the same velocity in different regions of the boundary layer. In the streamwise-spanwise plane, elongated streaky structures are observed in the log-law region, and disappear in the outer region of the boundary layer, which is contrary to the flow visualization results. | HE Lin YI ShiHe ZHAO YuXin TIAN LiFeng CHEN Zhi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，9： | 6 |
| 14 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 15 | Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers显示文摘It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices.Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes.Our recent report on lithium hexamethyldisilazide-initiated superfast polymerization on amino acid N-carboxyanhydrides enables the quick synthesis of host defense peptide-mimicking peptide polymers.Here we reported a facile and cost-effective thermoplastic polyurethane(TPU)surface modification of peptide polymer(DLL:BLG=90:10)using plasma surface activation and substitution reaction between thiol and bromide groups.The peptide polymer-modified TPU surfaces exhibited board-spectrum antibacterial property as well as effective contact-killing ability in vitro.Furthermore,the peptide polymer-modified TPU surfaces showed excellent biocompatibility,displaying no hemolysis and cytotoxicity.In vivo study using methicillin-resistant Staphylococcus aureus(MRSA)for subcutaneous implantation infectious model showed that peptide polymer-modified TPU surfaces revealed obvious suppression of infection and great histocompatibility,compared to bare TPU surfaces.We further explored the antimicrobial mechanism of the peptide polymer-modified TPU surfaces,which revealed a surface contact-killing mechanism by disrupting the bacterial membrane.These results demonstrated great potential of the peptide-modified TPU surfaces for practical application to combat bacterial infections that are associated with implantable materials and devices. | Ziyi Lu Yueming Wu Zihao Cong Yuxin Qian Xue Wu Ning Shao Zhongqian Qiao Haodong Zhang Yunrui She Kang Chen Hengxue Xiang Bin Sun Qian Yu Yuan Yuan Haodong Lin Meifang Zhu Runhui Liu | 2021 | Bioactive Materials2021，6，12： | 5 |
| 16 | Inducing Flow Velocities to Manage Fish Reproduction in Regulated Rivers显示文摘Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir. | Qiuwen Chen Jianyun Zhang Yuchen Chen Kangle Mo Jun Wang Lei Tang Yuqing Lin Lei Chen Yong Gao Wei Jiang Yuxin Zhang | 2021 | Engineering2021，7，2： | 4 |
| 17 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 18 | 比利时水下文化遗产立法对我国《水下文物保护管理条例》修订的参考意义显示文摘《中华人民共和国水下文物保护管理条例》(以下简称“《条例》”)正在修订当中,与此同时,我国正在积极考虑加入《保护水下文化遗产公约》(以下简称“《公约》”)。为了使《条例》尽量符合《公约》的精神,在《条例》的修订过程中,《公约》的规定是不可避免的考虑因素。《公约》至今为止有60 个缔约国,而比利时是少数根据《公约》规定,重新订立相关法律的缔约国之一。虽然我国还没有加入《公约》,但是此时修订《条例》不可能不考虑《公约》的影响。了解缔约国在加入《公约》后对其本国立法作出何种调整,以及作出调整的原因,对我国目前正在进行的《条例》修订工作有着重要的参考意义。 | 林蓁 HUANG Yuxin LIN Fenglai | 2019 | 中华海洋法学评论2019，15，1： | 3 |
| 19 | Nucleic acids and analogs for bone regeneration显示文摘With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids(deoxyribonucleic acid or ribonucleic acid)and nucleic acid analogs(peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed. | Yuxin Zhang Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Xueping Xie Xiawei Wei Yunfeng Lin | 2018 | Bone Research2018，6，4： | 3 |
| 20 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
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