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| 1 | Prospective controlled study on the effects of polyethylene glycol in capsule endoscopy显示文摘AIM:To prospectively confirm whether a small amount of polyethylene glycol(PEG)ingested after swallowing endoscopy capsule improves image quality and completion rate.METHODS:Forty-four consecutive patients referred to us for capsule endoscopy(CE)were randomized to two groups.All patients were restricted to clear fluids for 12 h before the examination.Patients in group A(22 cases)received no additional preparation,while those in group B(20 cases)ingested 500 mL of PEG within a 2 h period starting 30 min after swallowing the capsule.Clear fluids and meals were allowed 2 h and 4 h after capsule ingestion,respectively.Image quality was assessed as the percentage of visualized bowel surface area as follows:1:<25%;2:25%-49%;3:50%-74%;4:75%-89%;5:>90%.The small bowel record was divided into five segments by time,and the score for each segment was evaluated.All CE examinations were performed with the Pillcam SB capsule endoscopy sys-tem(Given Imaging Co.Ltd.,Yoqnem).RESULTS:This study ended in December 2009,because sample size was considered large enough.A total of 44 patients were enrolled.Two patients in group B were excluded from the analysis because small bowel images could not be obtained from these patients;one had a full stomach,while the other presented with a massive gastric bleed.Thus,22 patients from group A and 20 patients from group B completed the study.There was no significant difference in age(P=0.22),sex(P=0.31),and indication for CE.No significant adverse events occurred in any of the study patients.In group A,image quality deteriorated as the capsule progressed distally.However,in group B,image quality was maintained to the distal small bowel.In each of the five segments,the visibility score was significantly higher in group B than in group A(segment 1:4.3± 0.7vs 4.7±0.5,P=0.03;segment 2:4.2±0.9vs 4.8 ±0.4,P=0.01;segment 3:4.0±1.0 vs 4.6±0.7,P =0.04;segment 4:3.6±1.1 vs 4.5±0.6,P=0.003;segment 5:2.7±1.0vs 4.4±0.8,P=0.00004).Thus,the use of PEG during CE examination significantly improved image quality in all time segments,and this effect was more pronounced in the distal ileum.The completion rate to the cecum was not significantly different between groups A and B(81.8%vs 85.0%,P =0.89).There was no difference in the gastric transit time between groups(36.2±35.0 min vs 54.0±56.6 min,P=0.23),but the small bowel transit time was significantly longer in group A than in group B(246.0± 107.0 minvs 171.0±104.0 min,P=0.04).CONCLUSION:The ingestion of a small amount of PEG after the swallowing of an endoscopy capsule significantly improved CE image quality,but did not enhance the completion rate to the cecum. | Takafumi Ito Ken Ohata Akiko Ono Hideyuki Chiba Yosuke Tsuji Hajime Sato Nobuyuki Matsuhashi | 2012 | World Journal of Gastroenterology2012，18，15： | 7 |
| 2 | Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video)显示文摘 | Yosuke Tsuji Ken Ohata Toshiaki Gunji Meiko Shozushima Jun Hamanaka Akiko Ohno Takafumi Ito Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2014 | Gastrointestinal Endoscopy2014，，1： | 2 |
| 3 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 2 |
| 4 | Bending shoots stimulates flowering and influences hormone levels in lateral budsof Japanese pear 显示文摘 | Akiko Ito Hideaki Yaegaki Hiroko Hayama | 1999 | HortScience1999，34，7： | 1 |
| 5 | Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis显示文摘 | Kaoru Ogawa Mikito Ito Kaori Takeuchi Akiko Nakada Masayuki Heishi Hajime Suto Kouichi Mitsuishi Yuji Sugita Hideoki Ogawa Chisei Ra | 2005 | Journal of Dermatological Science2005，，： | 1 |
| 6 | Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study显示文摘AIM To examine the relationship between pancreatic hyperechogenicity and risk factors for metabolic syndrome.METHODS A general population-based survey of lifestyle-related diseases was conducted from 2005 to 2006 in Japan. The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. The echogenicity of the pancreas and liver was compared, and then the subjects were separated into two groups: cases with pancreatic hyperechogenicity(n = 208) and cases without(controls, n = 264). The differences between both groups were compared using an unpaired t-test or Fisher's exact test. Multiple logistic regression analysis was used to determine the relationship between the pancreatic hyperechogenicity and clinical and bio-chemical parameters.RESULTS Subjects with pancreatic hyperechogenicity had decreased serum adiponectin concentration compared to control subjects [8.9(6.5, 12.8) vs 11.1(7.8, 15.9), P < 0.001] and more frequently exhibited features of metabolic syndrome. Logistic regression analysis showed that the following variables were significantly and independently associated with pancreatic hyperechogenicity: Presence of hypoadiponectinemia, increased body mass index(BMI), higher homeostasis model assessment of insulin resistance(HOMA-IR) score, and presence of fatty liver. Similar associations were also observed in subjects with pancreatic hyperechogenicity without fatty liver. Multivariate association analysis of data from participants without fatty liver showed that hypoadiponectinemia was significantly associated with pancreatic hyperechogenicity(OR = 0.93, 95%CI: 0.90- 0.97, P < 0.001). This association was independent of other confounding variables. Additionally, an increased BMI and higher HOMA-IR score were significantly associated with pancreatic hyperechogenicity.CONCLUSION Pancreatic hyperechogenicity is independently associated with increased BMI, insulin resistance, and hypoadiponectinemia in the general population. | Naohiko Makino Nakao Shirahata Teiichiro Honda Yoshiaki Ando Akiko Matsuda Yushi Ikeda Miho Ito Yuko Nishise Takafumi Saito Yoshiyuki Ueno Sumio Kawata | 2016 | World Journal of Hepatology2016，8，33： | 1 |
| 7 | Effects of PPARγ Agonists against Vascular and Renal Dysfunction显示文摘 | Akira Sugawara Akira Uruno Ken Matsuda Takako Saito-Ito Tadao Funato Akiko Saito-Hakoda Masataka Kudo Sadayoshi Ito | 2012 | Current Molecular Pharmacology2012，，2： | 1 |
| 8 | Highly divergent sequences of the pollen self-incompatibility ( S ) gene in class-I S haplotypes of Brassica campestris (syn. rapa ) L.显示文摘 | Masao Watanabe Akiko Ito Yoshinobu Takada Chie Ninomiya Tomohiro Kakizaki Yoshihito Takahata Katsunori Hatakeyama Kokichi Hinata Go Suzuki Takeshi Takasaki Yoko Satta Hiroshi Shiba Seiji Takayama Akira Isogai | 2000 | FEBS Letters2000，，2： | 1 |
| 9 | Varietal differences in root growth as related to nitrogen uptake by sorghum plants in low-nitrogen environment显示文摘 | Takuji Nakamura Joseph J. Adu-Gyamfi Akiko Yamamoto Satoru Ishikawa Hiroshi Nakano Osamu Ito | 2002 | Plant and Soil2002，，1： | 1 |
| 10 | Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas显示文摘 | Yosuke Tsuji Ken Ohata Masau Sekiguchi Akiko Ohno Takafumi Ito Hideyuki Chiba Toshiaki Gunji Jun-ichi Fukushima Nobutake Yamamichi Mitsuhiro Fujishiro Nobuyuki Matsuhashi Kazuhiko Koike | 2012 | Gastric Cancer2012，，4： | 1 |
| 11 | Surgical strategy for gastric gastrointestinal stromal tumors: laparoscopic vs. open resection显示文摘 | Junichi Nishimura Kiyokazu Nakajima Takeshi Omori Tsuyoshi Takahashi Akiko Nishitani Toshinori Ito Toshirou Nishida | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 12 | Large-scale DNA polymorphism study of Oryza sativa and O. rufipogon reveals the origin and divergence of Asian rice显示文摘 | Sujay Rakshit Arunita Rakshit Hideo Matsumura Yoshihiro Takahashi Yoshitaka Hasegawa Akiko Ito Takashige Ishii Naohiko T. Miyashita Ryohei Terauchi | 2007 | Theoretical and Applied Genetics2007，，4： | 1 |
| 13 | Analysis of Expression Patterns of Breast Cancer-Specific Markers (Mammaglobin and Gross Cystic Disease Fluid Protein 15) in Lung and Pleural Tumors显示文摘 | Takeda Yuji Tsuta Koji Shibuki Yasuo Hoshino Tatsuhiro Tochigi Naobumi Maeshima Akiko Miyagi Asamura Hisao Sasajima Yuko Ito Tsuyoshi Matsuno Yoshihiro | 2008 | Archives of Pathology & Laboratory Medicine2008，，2： | 1 |
| 14 | Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer显示文摘 | Levent B. Beder Mehmet Gunduz Mamoru Ouchida Esra Gunduz Akiko Sakai Kunihiro Fukushima Hitoshi Nagatsuka Sachio Ito Noriyasu Honjo Kazunori Nishizaki Kenji Shimizu | 2006 | Journal of Cancer Research and Clinical Oncology2006，，1： | 1 |
| 15 | Gene expression analysis of plant host-pathogen interactions by SuperSAG显示文摘 | Reich S Akiko Ito | 2003 | PNAS2003，100，15： | 1 |
| 16 | OsHap3 genes regulate chloroplast biogenesiss in rice显示文摘 | Kazumaru Miyoshi Yukihiro Ito Akiko Serizawa | 2003 | The Plant Journal2003，36，4： | 1 |
| 17 | Intraventricular Dyssynchrony May Play a Role in the Development of Mitral Regurgitation in Dilated Cardiomyopathy显示文摘 | Akiko Soyama Tatsuji Kono Takayuki Mishima Hideaki Morita Takahide Ito Michihiro Suwa Yasushi Kitaura | 2005 | Journal of Cardiac Failure2005，，： | 1 |
| 18 | Surgical strategy for gastric gastrointestinal stromal tumors: laparoscopic vs. open resection显示文摘 | Junichi Nishimura Kiyokazu Nakajima Takeshi Omori Tsuyoshi Takahashi Akiko Nishitani Toshinori Ito Toshirou Nishida | 2007 | Surgical Endoscopy2007，，6： | 1 |
| 19 | Is Decompressive Surgery Effective for Spinal Cord Sarcoidosis Accompanied With Compressive Cervical Myelopathy?显示文摘 | Yoshihito Sakai Yukihiro Matsuyama Shiro Imagama Zenya Ito Norimitsu Wakao Naoki Ishiguro Hirohisa Watanabe Fumihiko Kato Yasutsugu Yukawa Keigo Ito Kazuhiro Suzuki Akiko Tsuboi Tokumi Kanemura Go Yoshida | 2010 | Spine2010，，23： | 1 |
| 20 | A nonclassical vitamin D receptor pathway suppresses renal fibrosis显示文摘 | Ito Ichiaki Waku Tsuyoshi Aoki Masato Abe Rumi Nagai Yu Watanabe Tatsuya Nakajima Yuka Ohkido Ichiro Yokoyama Keitaro Miyachi Hiroyuki Shimizu Toshiyuki Murayama Akiko Kishimoto Hiroyuki Nagasawa Kazuo Yanagisawa Junn | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
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