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| 1 | Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica显示文摘Aquaporin-4 (AQP4 ) 是在整个中央神经系统在星形细胞,以及在肾,肺,胃和骨胳的肌肉表示的水选择的 transporter。二 AQP4 isoforms 由其他的 spicing, M1 和 M23 AQP4 生产了,形式 heterotetramers 在称为粒子(OAP ) 的直角的数组的超分子的结构集合在房间血浆膜。AQP4 空的老鼠的显型分析在大脑和针的绳索水显示 AQP4 的参与平衡,星形细胞迁居,神经信号 transduction 和 neuroinflammation。AQP4 空的老鼠表明减少的大脑在细胞毒素的服的浮肿,但是增加的大脑在 vasogenic 浮肿和脑水肿胀大胀大。AQP4 缺乏也增加抓住持续时间,损害 glial 结疤,并且减少自体免疫的 neuroinflammation 的严厉。每这些显型根据在 AQP4 缺乏的减少的星形细胞水渗透是多半可解释的。AQP4 也涉及 neuroinflammatory demyelinating 疾病 neuromyelitis optica (NMO ) ,在指向 AQP4 的自身抗体(NMO-IgG ) 生产星形细胞损坏和发炎的地方。管理 NMO-IgG 和人由 intracerebral 注射补充的老鼠与 neuroinflammation, demyelination, perivascular 补充免职和 glial fibrillary 的损失开发典型 NMO 损害酸的蛋白质和 AQP4 immunoreactivity。我们的调查结果建议基于 AQP4 的治疗学的潜在的实用程序包括为大脑胀大,损害和癫痫的治疗的 AQP4 水运输功能的小分子的调节的人,以及小分子或对为 NMO 的治疗的 AQP4 有约束力的 NMO-IgG 的 monoclonal 抗体 blockers。 | Alan S VERKMAN Julien RATELADE Andrea ROSSI Hua ZHANG Lukmanee TRADTRANTIP | 2011 | Acta Pharmacologica Sinica2011，32，6： | 17 |
| 2 | Impaired coagulation,liver dysfunction and COVID-19:Discovering an intriguing relationship显示文摘Coronavirus disease 2019(COVID-19)is,at present,one of the most relevant global health problems.In the literature hepatic alterations have been described in COVID-19 patients,and they are mainly represented by worsening of underlying chronic liver disease leading to hepatic decompensation and liver failure with higher mortality.Several potential mechanisms used by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)to cause liver damage have been hypothesized.COVID-19 primary liver injury is less common than secondary liver injury.Most of the available data demonstrate how liver damage in SARSCo V-2 infection is likely due to systemic inflammation,and it is less likely mediated by a cytopathic effect directed on liver cells.Moreover,liver alterations could be caused by hypoxic injury and drugs(antibiotics and non-steroidal antiinflammatory drugs,remdesivir,tocilizumab,tofacitinib and dexamethasone).SARS-Co V-2 infection can induce multiple vascular district atherothrombosis by affecting simultaneously cerebral,coronary and peripheral vascular beds.Data in the literature highlight how the virus triggers an exaggerated immune response,which added to the cytopathic effect of the virus can induce endothelial damage and a prothrombotic dysregulation of hemostasis.This leads to a higher incidence of symptomatic and confirmed venous thrombosis and of pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in COVID-19.There are currently fewer data for arterial thrombosis,while myocardial injury was identified in 7%-17%of patients hospitalized with SARS-Co V-2 infection and 22%-31%in the intensive care unit setting.Available data also revealed a higher occurrence of stroke and more serious forms of peripheral arterial disease in COVID-19 patients.Hemostasis dysregulation is observed during the COVID-19 course.Lower platelet count,mildly increased prothrombin time and increased Ddimer are typical laboratory features of patients with severe SARS-Co V-2 infection,described as“COVID-19 associated coagulopathy.”These alterations are correlated to poor outcomes.Moreover,patients with severe SARS-Co V-2 infection are characterized by high levels of von Willebrand factor with subsequent ADAMTS13 deficiency and impaired fibrinolysis.Platelet hyperreactivity,hypercoagulability and hypofibrinolysis during SARS-Co V-2 infection induce a pathological state named as“immuno-thromboinflammation.”Finally,liver dysfunction and coagulopathy are often observed at the same time in patients with COVID-19.The hypothesis that liver dysfunction could be mediated by microvascular thrombosis has been supported by postmortem findings and extensive vascular portal and sinusoidal thrombosis observation.Other evidence has shown a correlation between coagulation and liver damage in COVID-19,underlined by the transaminase association with coagulopathy,identified through laboratory markers such as prothrombin time,international normalized ratio,fibrinogen,D-dimer,fibrin/fibrinogen degradation products and platelet count.Other possible mechanisms like immunogenesis of COVID-19 damage or massive pericyte activation with consequent vessel wall fibrosis have been suggested. | Damiano D'Ardes Andrea Boccatonda Giulio Cocco Stefano Fabiani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone Francesco Cipollone | 2022 | World Journal of Gastroenterology2022，28，11： | 5 |
| 3 | Aquaporin-4 Mz Isoform:Brain Expression,Supramolecular Assembly and Neuromyelitis Optica Antibody Binding显示文摘水通道蛋白4(AQP4)表达于大脑和脊髓的星形胶质细胞。2种主要的AQP4亚型,M1和M23,均有表达,具有不同的翻译起始点。研究表明,一种较新的亚型Mz表达于大鼠,其翻译起始点位于M1的翻译起始点上游126 bp。通过C端标记的抗AQP4抗体SDS和非变性胶免疫印迹技术,大鼠大脑中的Mz被检测到为39 kDa大小的条带。Mz因其提前终止密码子,在人类和小鼠大脑中并不表达。通过单粒子追踪和非变性胶电泳技术检测,发现大鼠Mz可形成正交粒子阵列(OAPs)。本文发现,Mz与M1类似,在细胞浆膜内迅速扩散,并不形成OAPs。但是,当与M23共表达时,Mz通过与M23形成异四聚体可与OAPs关联。意外的是,Mz表达的细胞极弱地与视神经脊髓炎自身抗体(NMO-IgG)结合,小于M1表达细胞的5倍。切割分析提示,Met-1上游的31~41残基参与NMO-IgG与Mz之间较弱的结合。总之,Mz AQP4在大鼠中低量表达,但不表达于人和小鼠的大脑;自身无法形成OAPs,除非与M23 AQP4形成异四聚体;因AQP4/NMO-IgG结合点的N端功能。 | Andrea Rossi Jonathan M.Crane A.S.Verkman | 2011 | 神经损伤与功能重建2011，6，5： | 4 |
| 4 | Real-time multiplex PCR assay to quantify hepatitis C virus RNA in peripheral blood mononuclear cells显示文摘 | Paolo Pugnale Patrizia Latorre Christine Rossi Katia Crovatto Valerio Pazienza Andrea De Gottardi Francesco Negro | 2005 | Journal of Virological Methods2005，，2： | 3 |
| 5 | Assessment and impact of diastolic function by echocardiography in elderly patients显示文摘Doppler echocardiography 是为对心脏舒张的机能障碍的评价的标准答案,它逐渐地作为心失败的一个原因被认出,在特别老。用 Doppler echocardiography 技术的联合,识别心脏舒张的机能障碍的等级是可能的,估计左室的充满压力并且建立心脏舒张的机能障碍的慢性。这些导出 physiologically 的措施广泛地对左心压力的侵略大小被验证了并且被显示了在大量临床的背景预示地珍贵。这评论探索机制,并且来临到对心脏舒张的机能障碍的评价在老。为临床医生的挑战是从与正常变老联系的那些识别 pathophysiological 变化。当在联合,和花的很长时间使用了进报道时, Doppler echocardiographic 参数在对在更老的病人的 dyspnoea 的评价是有用的并且提供预示的卓见。 | Clementina Dugo Marzia Rigolli Andrea Rossi Gillian A Whalley | 2016 | Journal of Geriatric Cardiology2016，13，3： | 3 |
| 6 | Extracorporeal membrane oxygenation in lung transplantation:Indications,techniques and results显示文摘The use of extracorporeal membrane oxygenation(ECMO)in the field of lung transplantation has rapidly expanded over the past 30 years.It has become an important tool in an increasing number of specialized centers as a bridge to transplantation and in the intra-operative and/or post-operative setting.ECMO is an extremely versatile tool in the field of lung transplantation as it can be used and adapted in different configurations with several potential cannulation sites according to the specific need of the recipient.For example,patients who need to be bridged to lung transplantation often have hypercapnic respiratory failure that may preferably benefit from veno-venous(VV)ECMO or peripheral veno-arterial(VA)ECMO in the case of hemodynamic instability.Moreover,in an intraoperative setting,VV ECMO can be maintained or switched to a VA ECMO.The routine use of intra-operative ECMO and its eventual prolongation in the postoperative period has been widely investigated in recent years by several important lung transplantation centers in order to assess the graft function and its potential protective role on primary graft dysfunction and on ischemia-reperfusion injury.This review will assess the current evidence on the role of ECMO in the different phases of lung transplantation,while analyzing different studies on pre,intra-and post-operative utilization of this extracorporeal support. | Eleonora Faccioli Stefano Terzi Alessandro Pangoni Ivan Lomangino Sara Rossi Andrea Lloret Giorgio Cannone Carlotta Marino Chiara Catelli Andrea Dell'Amore | 2021 | World Journal of Transplantation2021，11，7： | 3 |
| 7 | MELD score is better than Child–Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt显示文摘 | Francesco Salerno Manuela Merli Massimo Cazzaniga Valentina Valeriano Plinio Rossi Andrea Lovaria Daniele Meregaglia Antonio Nicolini Lorenzo Lubatti Oliviero Riggio | 2002 | Journal of Hepatology2002，，4： | 2 |
| 8 | Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery显示文摘Since the 19th century,appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors.This approach can be applied to any surgery for gastrointestinal cancer.During surgery for colon and rectal cancer,an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease.The adequate number of lymph nodes to be removed is standardized and reported by several guidelines.It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients.Our review focuses on the concept of“complete mesenteric excision(CME)with central vascular ligation(CVL),”a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years.The aim of this study was to evaluate the evolution of this approach over the years,its potential oncologic benefits and potential risks,and the improvements offered by laparoscopic techniques.Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin(CVL)which guarantees removal of a larger number of lymph nodes.The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery,providing the same oncologic results as open surgery.This has been widely applied to colorectal cancer surgery;however,CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzesresults of these procedures in terms of oncological outcomes, technical feasibilityand complexity, especially within the context of minimally invasive surgery. | Marzia Franceschilli Sara Di Carlo Danilo Vinci Bruno Sensi Leandro Siragusa Vittoria Bellato Roberto Caronna Piero Rossi Giuseppe Cavallaro Andrea Guida Simone Sibio | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 9 | Carbon Dioxide Capture Using Gas Hydrate Technology显示文摘 | Beatrice Castellani Mirko Filipponi Andrea Nicolini Franco Cotana Federico Rossi | 2013 | Journal of Energy and Power Engineering2013，7，5： | 2 |
| 10 | 意大利临床实践中的PDE5抑制剂治疗模式:“勃起功能障碍观测研究”的纵向数据显示文摘“勃起功能障碍观测研究”(Erectile Dysfunction Observational Study,EDOS)是一项为期6个月的多中心前瞻性研究,研究对象包括被要求开始接受治疗或改变治疗方式的ED病人。本研究旨在分析ED的治疗模式,并比较不同治疗模式的疗效。研究对象为到医院看病并诊断需要进行ED治疗的患者。他们接受ED治疗,并在治疗开始时、治疗3个月、6个月时回答来自IIEF(International Index of Erectile Function),EDITS(Erectile Dysfunction Inventory of Treatment Satisfaction),SF-PAIRS(Short Form of the Psychological and Interpersonal Relationship Scale)/nq卷的问题。医生可以给病人开出市场上现有的任何疗法,并可以在治疗过程中任何时间改变疗法。在完成为期6个月的分析的1338名病人中,有624人(47%)改变了疗法,714人(53%)一直接受最初诊断的疗法,其中接受治疗的病人持续接受一种疗法的比率显著高于接受西地那非或伐地那非治疗的病人。其它影响这一比率的变量包括性欲低下和ED。各种PDE-5抑制剂在效力、病人满意度、自信心、自发性等方面无显著差异。接受他达拉非治疗的病人的SF—PAIRS“时间相关”项的分数显著优于接受其它治疗的病人。结果显示现有的三种PDE-5抑制剂的临床实践和临床实验结果相似,但病人如果要终止或改变用药,他达拉非的风险较低。 | Ferdinando Fusco Riccardo Sicuteri Andrea Rossi Stathis Kontodimas Jose Maria Haro Ciro Imbimbo 无 | 2009 | Asian Journal of Andrology2009，11，5： | 2 |
| 11 | An exploratory study of the relation between supply chain topological features and supply chain performance显示文摘 | Margherita Pero Tommaso Rossi Carlo Noe Andrea Sianesi | 2012 | Intemational Joumal of Production Economics2012，，2： | 1 |
| 12 | Inferior Olivary Nucleus Involvement in Pediatric Neurodegenerative Disorders: Does It Play a Role in Neuroimaging Pattern-Recognition Approach?显示文摘 | Marisol Mirabelli-Badenier Giovanni Morana Claudio Bruno Maja Di Rocco Pasaquale Striano Eusa De Grandis Edvige Veneselli Andrea Rossi Roberta Biancheri | 2015 | Neuropediatrics2015，，： | 1 |
| 13 | MRI to assess renal structure and function显示文摘 | Ferruh Artunc Cristina Rossi Andreas Boss | 2011 | Current Opinion in Nephrology and Hypertension2011，，6： | 1 |
| 14 | Failure of aldosterone suppression despite angiotensin-converting enzyme (ACE) inhibitor administration in chronic heart failure is associated with ACE DD genotype显示文摘 | Mariantonietta Cicoira Luisa Zanolla Andrea Rossi Giorgio Golia Lorenzo Franceschini Giulio Cabrini Alberto Bonizzato Maristella Graziani Stefan D Anker Andrew J.S Coats Piero Zardini | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 15 | Flexible Job-shop Scheduling with Routing Flexibility and Separable Setup Times Using Ant Colony Optimization Method 显示文摘 | ROSSI Andrea DINI Gino | 2007 | Robotics and Com- puter-Integrated Manufacturing2007，23，5： | 1 |
| 16 | Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation显示文摘 | Patrizia Gazzerro Ciro Abbondanza Andrea D’Arcangelo Mariangela Rossi Nicola Medici Bruno Moncharmont Giovanni Alfredo Puca | 2005 | Experimental Cell Research2005，，3： | 1 |
| 17 | Oxalip|atin-related neurotoxicity: how and why? 显示文摘 | Pasetto LM D'Andrea MR Rossi E | 2006 | Crit Rev Oncol Hematol2006，59，2： | 1 |
| 18 | Oxaliplatinrelated neurotoxicity:how and why显示文摘 | Pasetto LM D'Andrea MR Rossi E | | 0，，02： | 1 |
| 19 | The current role of cardiac resynchronization therapy in reducing mortality and hospitalization in heart failure patients: a meta-analysis from clinical trials显示文摘 | Andrea Rossi Giuseppe Rossi Marcello Piacenti Umberto Startari Luca Panchetti Maria-Aurora Morales | 2008 | Heart and Vessels2008，，4： | 1 |
| 20 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Simone Rossi Del Monte Danilo Ranieri Francesca Mazzetta Andrea Kazemi Nava Salvatore Raffa Maria Rosaria Torrisi Vincenzo Ziparo | 2012 | J Surg Oncol2012，，1： | 1 |
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