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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis显示文摘Baicalein, wogonin,和他们的 glycosides 是在药用的植物黄芩 baicalensis Georgi 发现的主要 bioactive 混合物。这些黄酮能在许多癌症房间线导致 apoptosis,但是没在正常房间上有效果。而且,他们为人的健康有许多另外的好处,例如抗氧化剂,抗病毒、肝保护的性质。这里,我们报导二 CYP450 酶, SbCYP82D1.1 和 SbCYP82D2 的隔离和描述,分别地,它在 S. 作为黄酮 6-hydroxylase (F6H ) 和黄酮 8-hydroxylase (F8H ) 工作 ? baicalensis。SbCYP82D1.1 为象 chrysin 和 apigenin 那样的黄酮有宽广底层特性并且在根和 S. 的天线部分为 baicalein 和 scutellarein 的生合成负责 ? baicalensis 分别地。当 SbCYP82D1.1 的表示被击倒时,当时, baicalin 和 baicalein 层次显著地被减少 chrysin glycosides 在毛乎乎的根积累。SbCYP82D2 是有高底层特性的 F8H,接受仅仅象它生产 norwogonin 的底层的 chrysin,尽管次要的 6-hydroxylation 活动能也被检测。种系发生的分析建议 SbCYP82D2 可能经由 neofunctionalization 跟随的基因复制从 SbCYP82D1.1 演变,祖先的 F6H 活动由此部分在导出的 SbCYP82D2 被保留。 | Qing Zhao Meng-Ying Cui Olesya Levsh Dongfeng Yang Jie Liu Jie Li Lionel Hill Lei Yang Yonghong Hu Jing-Ke Weng Xiao-Ya Chen Cathie Martin | 2018 | Molecular Plant2018，11，1： | 30 |
| 3 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 4 | Tiller Bud Formation Regulators MOC1 and MOC3 Cooperatively Promote Tiller Bud Outgrowth by Activating F0N1 Expression in Rice显示文摘Tillering in rice is one of the most important agronomic traits.Rice tiller development can be divided into two main processes: the formation of the axillary bud and its subsequent outgrowth.Several genes critical for bud formation in rice have been identified by genetic studies;however,their molecular functions and relationships are still largely unknown.Here,we report that MONOCULM 1 (MOC1) and MONOCULM 3/ TILLERS ABSENT 1/STERILE AND REDUCED TILLERING 1 (MOC3/TAB1/SRT1),two vital regulators for tiller formation in rice,physically interact to regulate tiller bud outgrowth through upregulating the expression of FLORAL ORGAN NUMBER 1 (FON1),the homolog of CLAVATA1 in rice.We found that M0C3 is able to directly bind the promoter ofFONI and subsequently activate FON1 expression.MOC1 functions as a coactivator of MOC3,whereas it could not directly bind the FON1 promoter,and further activated FON1 expression in the presence of MOC3.Accordingly,FON1 is highly expressed at axillary meristems and shows remarkably decreased expression levels in mod and moc3 mutants.Loss-of-function mutants of FON1 exhibit normal bud formation but defective bud outgrowth and reduced tiller number.Collectively,these results shed light on a joint transcriptional regulatory mechanim by MOC1 and MOC3,and establish a new framework for the control of tiller bud formation and outgrowth. | Gaoneng Shao Zefu Lu Jinsong Xiong Bing Wang Yanhui Jing Xiangbing Meng Guifu Liu Haiyan Ma Yan Liang Fan Chen Yonghong Wang Jiayang Li Hong Yu | 2019 | Molecular Plant2019，12，8： | 15 |
| 5 | Admission clinical characteristics and early clinical outcomes among acute ischemic stroke patients显示文摘The purpose of the present study was to investigate the association between admission clinical characteristics and outcomes at discharge among acute ischemic stroke patients in the Chinese population.A total of 2,673 patients with acute ischemic stroke were included in the present study.The clinical characteristics at admission and other study variables were collected for all patients.The study outcome was defined as neurological deficiency(National Institute of Health Stroke Scale score ≥ 10) at discharge or in-hospital death.Compared with the subjects without neurological deficiency at discharge or in-hospital death,the subjects with neurological deficiency at discharge or in-hospital death had a significantly higher prevalence of hyperglycemia or history of atrial fibrillation at admission.Age≥ 80 years,hyperglycemia,hypertension,and history of atrial fibrillation were significantly associated with neurological deficiency at discharge or in-hospital death after adjustment for other variables.It is concluded that old age(≥ 80 years),hyperglycemia,hypertension and history of atrial fibrillation are significantly associated with neurological deficiency at discharge or in-hospital death among patients with acute ischemic stroke. | Xin Gao Jintao Zhang Ying Peng Huanqing Fan Mei Chen Tan Xu Yonghong Zhang | 2012 | The Journal of Biomedical Research2012，26，3： | 13 |
| 6 | The BUD2 mutation affects plant architecture through altering cytokinin and auxin responses in Arabidopsis显示文摘植物生长素和细胞激动素的比率在由支持或镇压调整天线建筑学起一个关键作用腋的芽长出。我们以前鉴别了显示的 Arabidopsis 变异的 bud2 改变了根和射击建筑学,它源于 S-adenosylmethionine decarboxylase 的 loss-of-function 4 (SAMDC4 ) 。在这研究,我们证明 BUD2 能被植物生长素导致,并且正式就职依赖于植物生长素发信号。BUD2 的变化导致弱敏到植物生长素和超敏性到细胞激动素,它被胼胝正式就职试金证实。我们的学习建议 polyamines 可以在通过影响细胞激动素和敏感的动态平衡到植物生长素和细胞激动素调整植物建筑学起他们的作用。 | Xia Cui Chunmin Ge Renxiao Wang Huanzhong Wang Weiqi Chen Zhiming Fu Xiangning Jiang Jiayang Li Yonghong Wang | 2010 | Cell Research2010，20，5： | 12 |
| 7 | A Dormant Multi-Controller Model for Software Defined Networking显示文摘In order to improve the scalability and reliability of Software Defined Networking(SDN),many studies use multiple controllers to constitute logically centralized control plane to provide load balancing and fail over.In this paper,we develop a flexible dormant multi-controller model based on the centralized multi-controller architecture.The dormant multi-controller model allows part of controllers to enter the dormant state under light traffic condition for saving system cost.Meanwhile,through queueing analysis,various performance measures of the system can be obtained.Moreover,we analyze the real traffic of China Education Network and use the results as the parameters of computer simulation and verify the effects of parameters on the system characteristics.Finally,a total expected cost function is established,and genetic algorithm is employed to find the optimal values of various parameters to minimize system cost for the deployment decision making. | FU Yonghong BI Jun WU Jianping CHEN Ze WANG Ke LUO Min | 2014 | China Communications2014，11，3： | 11 |
| 8 | Optimal Design for an End Face Engagement Worm Gear with Multiple Worm-wheel Meshing显示文摘To solve the problem for lacking a special mechanical transmission that could provide multiple outputs with high transmission efficiency and good lubrication in the modern industrial, a novel worm gear, named end face engagement worm gear, with multiple worm-wheel meshing is proposed for the first time. The essential parameters for the worm gear are optimized to enhance lubrication and meshing properties. Moreover, analysis of variance(ANOVA) is applied to determine the optimum levels and to determine the influence of parameters. The ANOVA results show that the novel end face engagement worm gear with multiple worm wheels provides high lubrication(the lubrication angle is more than 89°) and meshing performance(the induce normal curvature is less than 0.0002 mm^(-1)). The interaction between center distance and roller slant distance most strongly influences the lubrication angle(contributed 51.6%), followed by the parameters of center distance(contributed 25.0%), roller slant distance(contributed 16.4%), tooth angle of gear, gear ratio, and roller radius. In addition, roller radius most strongly influences the induced normal curvature(contributed 39.4%), followed by roller slant distance(contributed 15.2%), tooth angle of the gear(contributed 9.0%), center distance, and gear ratio. The proposed worm gear helps to enrich the no-backlash high precision worm drive and the optimal design method can provide a useful reference on performance improvement of other worm gear. | DENG Xingqiao ZHU Weibing CHEN Yonghong CHEN Shouan WANG Jinge | 2017 | Chinese Journal of Mechanical Engineering2017，30，1： | 9 |
| 9 | Impact of rock anisotropy on fracture development显示文摘的实验单轴并且 triaxial 岩石力学和岩石声学的排出物被在 Ordos 盆以内在上面的三叠纪的 Yanchang 形成作为一个例子拿 ultra-low-permeability 沙岩水库为关于不同方向的破裂的发展的关于岩石 anisotropy 的影响的研究进行了。试验性的结果在飞机上在不同方向证明岩石的 anisotropy 的存在是机械性质,它是为在在地质的经期的破裂的不同集合的发展的影响的生产的主要原因。岩石 anisotropy 通常限制一个集合的发展结合砍破裂。在 Ordos 盆主要是的在内的 Yanchang 形成的破裂砍在二个构造行动下面形成了的破裂。理论上,这里四个集合砍破裂应该发展了,但是由于强壮的岩石 anisotropy 的效果,在每个时期,破裂的一个集合主要发展了。因此,破裂的二个集合通常目前在每部分被开发。 | Lianbo Zeng Jiyong Zhao Shengju Zhu Weiliang Xiong Yonghong He Jianwen Chen | 2008 | Progress in Natural Science:Materials International2008，18，11： | 7 |
| 10 | From Basin Black Shales to Platform Carbonate Rocks:A Study on Sequence Stratigraphy for the Lower Cambrian of the Upper-Yangtze Region in South China显示文摘在 Upper-Yangtze 区域,特别在贵州省和它的邻近的区域,更低寒武纪很好被开发并且由从盆外形的黑页岩的继任是显著的焦化站台外形的岩石。从 Sinian 发生在拐弯到的站台的淹死的事件寒武纪导致了一套黑页岩,即 Niutitang 形成,它完成底部部分更低寒武纪。与沉积环境变浅,一套碳酸盐摇,即 Qingxudong 形成,在最高的部分被形成更低寒武纪。因此,更低在学习区域寒武纪使能进一步的一个秒顺序序列起来细分进五个第三顺序的序列,并且形成违反回归的定期周期的继任。为在秒顺序顺序的第三顺序的序列有一个定期垂直的叠模式。从底部到顶,继任“ CS (压缩的节)+HST (高看台的系统道) ”第三顺序的序列被变成继任“ TST (transgressive 系统道)+CS+HST' 。相应地,淹死类型顺序边界被变成暴露类型那条。因此,秒顺序和第三顺序的序列有类似的沉积外形的体系结构。有这些时间的变化的伴随物,更低与包含五个第三顺序的序列的 1000 m 的厚度寒武纪被变成不能与加深沉积环境向东南识别第三顺序的序列的压缩继任。根据第三顺序的序列的基本特征,即整齐 o 在空间和沉积环境的变化的同步性的沉积外形的继任及时,在在不同 paleogeographical 背景的主要的记载的节的第三顺序的序列的详细部门成为基础建立能在 stratigraphic 记录表明改变外形的表面的二种类型和 diachronism 的二种类型的 sequence-stratigraphic 框架。这个 sequence-stratigraphic 框架从盆外形的黑页岩形成的压缩继任的库显示出碳酸盐平台的成长进程。从 Sinian 在拐弯源于快速的违反到寒武纪生态的空间变得开,它形成了为“寒武纪的生物爆炸”设定的 paleogeographical 的先前的条件。最终,在 depositional 事件之间的基因关系和生物差异的事件是很复杂的并且在那里仍然是以后需要推进研究的大量问题。 | MEI Mingxiang MA Yongsheng ZHANG Hai MENG Xiaoqing CHEN Yonghong | 2007 | Acta Geologica Sinica(English Edition)2007，81，5： | 6 |
| 11 | Effectiveness of ZiYin Xiehuo granules and Zishen Qinggan granules on partial precocious puberty in girls: a multicenter, randomized, single-blind, controlled trial显示文摘OBJECTIVE: To evaluate the effect of ZiYin Xiehuo granules(ZYXH) and Zishen Qinggan granules(ZSQG) on partial precocious puberty(PPP).METHODS: This was a multicenter, randomized, single-blind, positive-controlled trial. A total of 143 pa-tients were assigned to either the ZYXH group or the ZSQG group using a random number table. The ZYXH group received ZYXH three times daily for 6 months and the ZSQG group received ZSQG three times daily for 6 months. Mammary nucleus diameter; the results of uterus, ovarian, and maximum follicle measures; and Chinese medicine symptom pattern scores were compared at baseline and after 3 months and 6 months of treatment.RESULTS: After 3 months' treatment, there were no significant differences between the two groups in mammary nucleus index changes(left 3.4 ± 3.1 vs3.5 ± 3.1, P = 0.790; right 3.0 ± 2.9 vs 3.6 ± 3.0, P =0.719). The uterine volume in the ZYXH group was smaller than that in the ZSQG group(2.1 ± 1.6 vs2.6 ± 2.2, P = 0.006). There were no significant between-group differences in ovarian volume and maximum follicular diameter on either side(ovarian volume: left 1.2 ± 0.7 vs 1.3 ± 0.6, P = 0.8; right1.2 ± 0.7 vs 1.4 ± 1.1, P = 0.984; maximum follicular diameter: left 3.9 ± 1.7 vs 3.5 ± 2.2, P = 0.158; right3.5 ± 1.7 vs 3.9 ± 2.1, P = 0.314).CONCLUSION: ZYXH granules and ZSQG granules both affected the size of the mammary nucleus in girls with PPP, and improved Chinese medicine symptom patterns. ZYXH granules showed slight advantages over ZSQG granules in terms of the decrease in the size of the uterus, ovaries, and ovarian follicles. | Sun Wen Han Xinghui Wang Yonghong Yu Jian Yan Weili Zhao Jun Chen Weibin Xue Zheng | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 5 |
| 12 | Comments on 2018 CPCS guideline for diagnosis and treatment of syncopein children and adolescents显示文摘Syncope is one kind of transient loss of consciousness,due to transient global cerebral hypoperfusion.It is sometimes misunderstood with other causes of transient loss of consciousness,like epilepsy,metabolic disorders,head trauma,psychological factors,and so on.Syncope in children and adolescents is common and seriously impacts the quality of their lives.However,its pathogenesis,etiologies,diagnosis and management are complex.The studies on syncope attract great interest of pediatricians and great progress has been made in this interesting field.Based on the improvement achieved so far,Chinese Pediatric Cardiology Society(CPCS)successfully developed a guideline for the diagnosis and treatment of syncope in children and adolescents,which would greatly improve the level of clinical management of syncope. | Chunyan Tao Xueqin Liu Chunyu Zhang Yonghong Chen? Yaqian Huang? | 2019 | Science Bulletin2019，64，5： | 5 |
| 13 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 14 | The First OCCCO Pentadentate Chelates:Osmium Mediated Stepwise Oxidations of Terminal Alkynes by Pyridine N-Oxide显示文摘of main observation and conclusion Oxygen atom transfer reactions between alkynes and heteroarene N-oxides are currently mediated by transition metal,such as gold,ruthenium or rhodium,but they have never been catalyzed by osmium.Herein,we report stepwise oxidations of terminal alkynes mediated by an osmium carbolong complex,using pyridine N-oxide as the oxidant,yielding novel aldehyde-or carboxylic acid-coordinated osmapentalyne derivatives selectively.The mechanism was illustrated by density functional theory calculations,providing a new route for oxygen atom transfer between heteroarene N-oxides and alkynes. | Jianfeng Lin Qiannan Xu Xinlei Lin Yuhui Hua Dafa Chen Yonghong Ruan Hong Zhang Haiping Xia | 2020 | Chinese Journal of Chemistry2020，38，11： | 4 |
| 15 | Energy Efficiency Optimization for Heterogeneous Cellular Networks Modeled by Matérn Hard-Core Point Process显示文摘The Poisson point process(PPP) has been widely used in wireless network modeling and performance analysis due to the independence between its nodes. Therefore, it may not be a suitable model for many of the exclusive networks between the nodes. This paper analyzes the energy efficiency(EE) and optimizes the two-tier heterogeneous cellular networks(Het Nets). Considering the mutual exclusion between macro base stations(MBSs) distribution, the deployment of MBSs is modeled by the Matérn hard-core point process(MHCPP), and the deployment of pico base stations(PBSs) is modeled by the PPP. We adopt a simple approximation method to study the signal to interference ratio(SIR) distribution in two-tier MHCPP-PPP networks and then derive the coverage probabilities, the average data rates and the energy efficiency of Het Nets. Finally, an optimization algorithm is proposed to improve the EE of Het Nets by controlling the transmit power of PBSs. The simulation results show that the EE of a system can be effectively improved by selecting the appropriate transmit power for the PBSs. In addition, two-tier MHCPP-PPP Het Nets have higher energy efficiency than two-tier PPP-PPP Het Nets. | Yonghong Chen Jie Yang Xuehong Cao Shibing Zhang | 2020 | China Communications2020，17，8： | 4 |
| 16 | COVID-19 epidemic prediction and the impact of public health interventions: A review of COVID-19 epidemic models显示文摘The coronavirus disease outbreak of 2019(COVID-19)has been spreading rapidly to all corners of the word,in a very complex manner.A key research focus is in predicting the development trend of COVID-19 scientifically through mathematical modelling.We conducted a systematic review of epidemic prediction models of COVID-19 and the public health intervention strategies by searching the Web of Science database.55 studies of the COVID-19 epidemic model were reviewed systematically.It was found that the COVID-19 epidemic models were different in the model type,acquisition method,hypothesis and distribution of key input parameters.Most studies used the gamma distribution to describe the key time period of COVID-19 infection,and some studies used the lognormal distribution,the Erlang distribution,and theWeibull distribution.The setting ranges of the incubation period,serial interval,infectious period and generation time were 4.9-7 days,4.41-8.4 days,2.3-10 days and 4.4-7.5 days,respectively,and more than half of the incubation periods were set to 5.1 or 5.2 days.Most models assumed that the latent period was consistent with the incubation period.Some models assumed that asymptomatic infections were infectious or pre-symptomatic transmission was possible,which overestimated the value of R0.For the prediction differences under different public health strategies,the most significant effect was in travel restrictions.There were different studies on the impact of contact tracking and social isolation,but it was considered that improving the quarantine rate and reporting rate,and the use of protective face mask were essential for epidemic prevention and control.The input epidemiological parameters of the prediction models had significant differences in the prediction of the severity of the epidemic spread.Therefore,prevention and control institutions should be cautious when formulating public health strategies by based on the prediction results of mathematical models. | Yue Xiang Yonghong Jia Linlin Chen Lei Guo Bizhen Shu Enshen Long | 2021 | Infectious Disease Modelling2021，6，1： | 3 |
| 17 | HGF percutaneous endocardial injection induces cardiomyocyte proliferation and rescues cardiac function in pigs显示文摘Objective:To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor(HGF)in pigs with chronic myocardial infarction(CMI).Methods:A steerable,deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI.Pigs were randomized(1:1:1)to receive adenoviral vector HGF(total dose,1×1010 genome copies),which was administered as five injections into the infarcted myocardium(total,1.0 mL),or saline,or Ad-null(control groups).Injections were guided by Ensite NavX left ventricular electroanatomical mapping.HGF and cyclin proteins were detected by western blot and immunoprecipitation analysis.Histological and immunohistochemical analysis determined proliferating cardiomyocytes.Myocardial perfusion and cardiac function were estimated by Gated-Single Photon Emission Computed Tomography(G-SPECT).Results:Western blot analyses showed that HGF were predominantly expressed in the infarct core and border in the myocardium of the infarcted heart.G-SPECT analysis indicated that the HGF group had better cardiac function and myocardial perfusion four weeks after the injection of Ad-HGF than before the injection of Ad-HGF.After treatment there were more proliferating cardiomyocytes in the HGF group compared to either of the control groups.Furthermore,the HGF group myocardial samples expressed higher levels of p-Akt,cyclin A,cyclin E,cyclin D1,cdk2,cdk4 than those in the control groups.Conclusion:The over-expression of HGF activates pro-survival pathways,induces cardiomyocyte proliferation,and improves the perfusion and function of the porcine CMI heart. | Zhengxian Tao Bo Chen Yingming Zhao Hongwu Chen Liansheng Wang Yonghong Yong Kejiang Cao Qifeng Yu Danian Ke` Hua Wang Zuze Wu Zhijian Yang | 2010 | The Journal of Biomedical Research2010，24，3： | 3 |
| 18 | Design, Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Tetrahydrophthalimide Substructure显示文摘 | HUA Xuewen ZHOU Sha CHEN Minggui ZHANG Dongkai LIU Ming LIU Jingbo WU Changchun LIU Yang LI Yonghong LI Zhengming | 2016 | Chemical Research in Chinese Universities2016，32，3： | 3 |
| 19 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 20 | The Major Controlling Factors and Different Oolitic Shoal Reservoir Characteristics of the Triassic Feixianguan Formation,Eastern Longgang Area,NE Sichuan Basin,SW China显示文摘Based on comprehensive analyses of occurrence,petrological observation,pore structure and geochemistry,the different reservoir characteristics and reservoir evolutionary pathways between different oolitic shoal reservoir types of the Feixianguan Formation on the west side of the Kaijiang-Liangping Trough have been studied.There exist three stages of high-energy slope break belts in the Feixianguan period,the corresponding three stages of oolitic shoals gradually migrating in the direction of the trough.Three types of oolitic shoal reservoirs,namely,residual-oolitic dolomite,mold-oolitic dolomite and sparry oolitic limestone,were formed during sedimentary-diagenetic evolution,the pore types being intergranular dissolved pore,mold pore(or intragranular dissolved pore)and residual intergranular pore,respectively.The petrology,physical properties and pore structure of the different types of oolitic shoal reservoirs are quite different.Residual-oolitic dolomite reservoirs have the best quality,while sparry oolitic limestone reservoirs have the poorest.Combined with analyses of trace elements,rare earth elements and carbon-oxygen isotopes,it is suggested that the formation of residual-oolitic dolomite reservoirs is jointly controlled by penesaline seawater seepage-reflux dolomitization and hydrothermal dolomitization.Mold-pore oolitic dolomite reservoirs are controlled by penesaline seawater seepage-reflux dolomitization and meteoric water solution.The burial dissolution of organic acid not only further improves the reservoir qualities of previously formed oolitic dolomite reservoirs,but also preserves residual intergranular pores in the sparry oolitic limestone reservoirs. | GU Yifan JIANG Yuqiang LEI Xiaohua CHEN Zhiyong ZHOU Lu FU Yonghong JIANG Zengzheng | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 3 |
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