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| 1 | Pancreatic metastases from renal cell carcinoma:The state of the art显示文摘Pancreatic metastases are rare,with a reported incidence varying from 1.6%to 11%in autopsy studies of patients with advanced malignancy.In clinical series,the frequency of pancreatic metastases ranges from 2%to 5%of all pancreatic malignant tumors.However,the pancreas is an elective site for metastases from carcinoma of the kidney and this peculiarity has been reported by several studies.The epidemiology,clinical presentation,and treatment of pancreatic metastases from renal cell carcinoma are known from singleinstitution case reports and literature reviews.Thereis currently very limited experience with the surgical resection of isolated pancreatic metastasis,and the role of surgery in the management of these patients has not been clearly defined.In fact,for many years pancreatic resections were associated with high rates of morbidity and mortality,and metastatic disease to the pancreas was considered to be a terminal-stage condition.More recently,a significant reduction in the operative risk following major pancreatic surgery has been demonstrated,thus extending the indication for these operations to patients with metastatic disease. | Roberto Ballarin Mario Spaggiari Nicola Cautero Nicola De Ruvo Roberto Montalti Cristina Longo Anna Pecchi Patrizia Giacobazzi Giuseppina De Marco Giuseppe D’Amico Giorgio Enrico Gerunda Fabrizio Di Benedetto | 2011 | World Journal of Gastroenterology2011，17，43： | 21 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Office hysteroscopy and compliance:mini-hysteroscopy versus traditional hysteroscopy in a randomized trial显示文摘 | Carlo D Giuseppina S Maria E | 2003 | Hum Reprod2003，18，： | 1 |
| 4 | Comparison of first and second trimester screening for fetal anomalies显示文摘 | Giuseppina D' Ottavio Giampaolo Mandruzzato Yoram J Meir | 2003 | Annals New York Academy Of Science2003，65，： | 1 |
| 5 | Pro-Inflammatory Cytokine Genes Influence the Clinical Features of Frontotemporal Lobar Degeneration显示文摘 | Rainero Innocenzo Rubino Elisa Cappa Giorgetta Rota Eugenia Valfrè Walter Ferrero Patrizia Fenoglio Pierpaola Baci Denisa D’amico Giuseppina Vaula Giovanna Gallone Salvatore Pinessi Lorenzo | 2009 | Dementia and Geriatric Cognitive Disorders2009，，6： | 1 |
| 6 | Allele and genotype frequencies of CYP2C9 , CYP2C19 and CYP2D6 in an Italian population显示文摘 | Maria Gabriella Scordo Achille P Caputi Concetta D’Arrigo Giuseppina Fava Edoardo Spina | 2004 | Pharmacological Research2004，，2： | 1 |
| 7 | U-PA and c-met mRNA espresslion is dom-regulated in human hepatocellular carcinomas显示文摘 | Daniela T Giuseppina D Anna B | 2000 | Int J Cancer2000，87，5： | 1 |
| 8 | A Specific miRNA Signature Correlates With Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer显示文摘 | Giuseppina Della Vittoria Scarpati Francesca Falcetta Chiara Carlomagno Paolo Ubezio Sergio Marchini Alfonso De Stefano Vijay Kumar Singh Maurizio D’Incalci Sabino De Placido Stefano Pepe | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 9 | Enzymologi- cal differences of AChE and diazinon hepatic metabolism: correlation of in vitro data with the selective toxicity of diazinon to fish species显示文摘 | Johannes Keizer Giuseppina D'Agostino Nagel R | 1995 | The Science of the Total Environment1995，171，： | 1 |
| 10 | Control of tracheal cuff pressure: a pilot study using a pneumatic device 显示文摘 | Alexandre Duguet Leda D' Amico Giuseppina Biondi | 2007 | Intensive Care Med2007，，33： | 1 |
| 11 | Small ubiquin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor 显示文摘 | LAUREN D W BRENDA J I GIUSEPPINA N | 2003 | PNAS2003，100，： | 1 |
| 12 | Cloning and developmental expression of the Xenopus homeobox gene Xvsx1显示文摘 | Silvia D’Autilia Sarah Decembrini Simona Casarosa Rong-Qiao He Giuseppina Barsacchi Federico Cremisi Massimiliano Andreazzoli | 2006 | Development Genes and Evolution2006，，12： | 1 |
| 13 | Anemia in diffuse large B-cell non-Hodgkin lymphoma: the role of interleukin-6, hepcidin and erythropoietin显示文摘 | Maria Chiara Tisi Valentina Bozzoli Manuela Giachelia Giuseppina Massini Bianca Maria Ricerca Elena Maiolo Francesco D&rsquo Alo&rsquo Luigi Maria Larocca Alfonso Piciocchi Harold Tjalsma Dorine W. Swinkels Maria Teresa Voso Giuseppe Leone Stefan Hohaus | 2014 | Leukemia & Lymphoma2014，，2： | 1 |
| 14 | Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia(tea tree)oil against Staphylococcus aureus and Escgerichia coli显示文摘 | Manuela D Giovanna G Giuseppina M | 2010 | Phytomedicine2010，17，5： | 1 |
| 15 | Effect of melatonin and pineal grafting on thymocyte aoptosis in aging mice 显示文摘 | Provinciali M Giuseppina DS Bulian D | 1996 | Mech Ageing Dev1996，90，1： | 1 |
| 16 | Serum levels of carbohydrate antigen 125 in patients with chronic heart failure显示文摘 | Antonio D'Aloia Pompilio Faggiano Gerard Aurigemma Luca Bontempi Giuseppina Ruggeri Marco Metra Savina Nodari Livio Dei Cas | 2003 | Journal of the American College of Cardiology2003，，10： | 1 |
| 17 | Detection of Mycobacterium tuberculosis Complex in Milk Using Polymerase Chain Reaction (PCR)显示文摘 | ANGELA D P GIUSEPPINA C TONY F V | 2006 | Food Control2006，17，： | 1 |
| 18 | Detectionof mycobacterium tuberculosis complex in milk using pol-ymerase chain reaction(PCR)显示文摘 | Angela D P Giuseppina C Tony F V | 2006 | Food control2006，10，： | 1 |
| 19 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products显示文摘 | Giuseppina B Guido L Serena D T | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 20 | Advanced glycation end products and vascular inflammation:implications for accelerated atherosclerosis in diabetes显示文摘 | Giuseppina B Ann M S Raffaele D C | 2004 | Cardiovascular Research2004，63，4： | 1 |
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