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| 1 | 大型浅水湖泊沉积物内源营养盐释放模式及其估算方法——以太湖为例显示文摘在新的野外调查和室内试验基础上,完善了有关大型浅水湖泊沉积物内源营养盐释放的模式,并在此基础上提出了太湖内源释放的估算方法。通过在太湖开展室内释放模拟实验和风浪期间底泥悬浮及上覆水中营养盐浓度变化的野外观测,提出了静态与动态二种浅水湖泊内源释放模式。静态情况下,营养盐主要通过浓度梯度扩散从沉积物进入上覆水,其释放强度受控于沉积物~水界面的温度,氧化还原环境及营养盐浓度差;动态条件下,沉积物由于动力扰动而发生悬浮,沉积物中溶解性及颗粒态的营养盐随着沉积物的悬浮而释放。虽然动态情况下总的营养盐释放较静态条件下大,但由于湍流导致水体及水土界面充氧,铁,锰等金属元素因氧化而吸附溶解性营养盐(特别是活性磷SRP)的能力增强,所以动力扰动仅引起总的营养盐释放,而不一定导致溶解性营养盐的释放。因此,在动态条件下,营养盐总释放量受控于动力扰动强度,底泥可悬浮量及沉积物中的营养盐含量;对于可溶性的营养盐,特别是SRP,其释放还受控于动力复氧的强度,沉积物中铁的含量及沉积物间隙水与上覆水中营养盐的浓度差。在此基础上,分别估算了静态和动态二种情况下沉积物内源释放量。根据实验室模拟结果,静态条件下太湖全湖一年NH_4^+-N释放量达1万吨左右,PO_4^(3-)-P释放量达900 t左右;结合太湖2001年的风场观测记录,把太湖野外风浪过程分为风平浪静,小风浪,大风浪三种情况,分别占全年总日数的12%,82%,6%在“风平浪静”条件下,其释放量根据实验室的静态释放试验来估算,而“小风浪”和“大风浪”条件下,其释放量则根据室内水槽试验得到的释放通量来估算。结果显示太湖全年释放量为总氮8.1万吨,总磷为2.1万吨;分别为外源氮磷年输入量的2-6倍。 | 秦伯强 朱广伟 张路 罗潋葱 高光 Gu Binghe | 2005 | 中国科学:地球科学2005，39，S2： | 113 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Elimination of interferents influence in simultaneous determination of organic gases using PLS with FTIR spectroscopy显示文摘 | GU Binghe WANG Lianjun WANG Junde | 1998 | Spectrosc Lett1998，31，7： | 1 |
| 4 | Biomorphic AI2 03 fibers synthesized using cotton as bio-tempIates 显示文摘 | FAN Tongxiang SUN Binghe GU Jiajun | 2005 | Scripta Materialia2005，53，： | 1 |
| 5 | Biomorphic Al 2 O 3 fibers synthesized using cotton as bio-templates显示文摘 | Tongxiang Fan Binghe Sun Jiajun Gu Di Zhang Leo W.M. Lau | 2005 | Scripta Materialia2005，，8： | 1 |
| 6 | Adjuvant tamoxifen switched to exemestane treatment in postmenopausal women with estrogen receptor-positive early breast cancer:A pragmatic,multicenter,and prospective clinical trial in China显示文摘Objective:This post-approval safety study assessed the efficacy and safety of exemestane after 2-3 years of tamoxifen treatment among postmenopausal women with estrogen receptor-positive(ER+)early breast cancer in China.Methods:Enrolled patients had received 2-3 years of tamoxifen and were then switched to exemestane for completion of 5 consecutive years of adjuvant endocrine therapy.The primary endpoint was the time from enrollment to the first occurrence of locoregional/distant recurrence of the primary breast cancer,appearance of a second primary or contralateral breast cancer,or death due to any cause.Other endpoints included the proportion of patients experiencing each event,incidence rate per annum,relationships between human epidermal growth factor receptor 2 status and time to event,and relationship between disease history variables and time to event.Results:Overall,558 patients were included in the full analysis set:397(71.1%)completed the study,20experienced an event,and 141 discontinued[47 owing to an adverse event(AE);37 no longer willing to participate].Median duration of treatment was 29.5(range,0.1-57.7)months.Median time to event was not reached.Eventfree survival probability at 36 months was 91.4%(95%CI,87.7%-95.1%).The event incidence over the total exposure time of exemestane therapy was 3.5 events/100 person-years(20/565).Multivariate analysis showed an association between tumor,lymph node,and metastasis stage at initial diagnosis and time to event[hazard ratio:1.532(95%CI,1.129-2.080);P=0.006].Most AEs were grade 1 or 2 in severity,with arthralgia(7.7%)being the most common treatment-related AE.Conclusions:This study supports the efficacy and safety of exemestane in postmenopausal Chinese women with ER+breast cancer previously treated with adjuvant tamoxifen for 2-3 years.No new safety signals were identified in the Chinese population. | Binghe Xu Huiping Li Zefei Jiang Lin Gu Jinhai Tang Hui Xie Yueyin Pan Yunjiang Liu Shude Cui Xiaojia Wang Li Cai Yiqiong Zhang Huadong Zhao Zhimin Shao | 2022 | Chinese Journal of Cancer Research2022，34，6： | 0 |
| 7 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
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