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| 1 | Cryo-EM structures of human m^(6)A writer complexes显示文摘N6-methyladenosine(m^(6)A)is the most abundant ribonucleotide modification among eukaryotic messenger RNAs.The m^(6)A“writer”consists of the catalytic subunit m^(6)A-METTL complex(MAC)and the regulatory subunit m^(6)A-METTL-associated complex(MACOM),the latter being essential for enzymatic activity.Here,we report the cryo-electron microscopy(cryo-EM)structures of MACOM at a 3.0-Åresolution,uncovering that WTAP and VIRMA form the core structure of MACOM and that ZC3H13 stretches the conformation by binding VIRMA.Furthermore,the 4.4-Åresolution cryo-EM map of the MACOM–MAC complex,combined with crosslinking mass spectrometry and GST pull-down analysis,elucidates a plausible model of the m^(6)A writer complex,in which MACOM binds to MAC mainly through WTAP and METTL3 interactions.In combination with in vitro RNA substrate binding and m^(6)A methyltransferase activity assays,our results illustrate the molecular basis of how MACOM assembles and interacts with MAC to form an active m^(6)A writer complex. | Shichen Su Shanshan Li Ting Deng Minsong Gao Yue Yin Baixing Wu Chao Peng Jianzhao Liu Jinbiao Ma Kaiming Zhang | 2022 | Cell Research2022，32，11： | 3 |
| 2 | Second Cohomology Group of Generalized Wity Type Lie Algebras and Certain Repre- sentations 显示文摘 | Yucai Su Kaiming Zhao | 2002 | Comunications in Algebra2002，30，7： | 1 |
| 3 | Simple Lie color algebras of Weyl type显示文摘 | SU YUCAI ZHAO KAIMING ZHU LINSHENG | 2003 | Israel J Math2003，137，： | 1 |
| 4 | Generalized Virasoro and super-Virasoro algebras and modules of intermediate series 显示文摘 | Su Yucai Zhao Kaiming | 2002 | J Alg2002，252，： | 1 |
| 5 | Quantitative study on hydrocarbon expulsion mechanism based on micro-fracture显示文摘The significance of source rocks for oil and gas accumulation has been indisputably acknowledged.Moreover,it has been gradually realized that there is difference between hydrocarbon generation capacity and hydrocarbon expulsion capacity,and this has prompted research on hydrocarbon expulsion efficiency.However,these studies dominantly highlight the results of hydrocarbon expulsion,and investigation into the corresponding process and mechanism is primarily from a macroscopic perspective.Despite its wide acceptance as the most direct hydrocarbon expulsion mode,hydrocarbon expulsion through micro-fractures is still not sufficiently understood.Therefore,this study obtains observations and performs experiments on two types of source rocks(mudstones and shales)of the Chang 7 oil group of the Yanchang Formation in Ordos Basin,China.Microscopy reveals that organic matter is non-uniformly distributed in both types of source rocks.Specifically,mudstones are characterized by a cluster-like organic matter distribution,whereas shales are characterized by a layered organic matter distribution.Thermal evolution simulation experiments demonstrate that the hydrocarbon generation process is accompanied by the emergence of micro-fractures,which are favorable for hydrocarbon expulsion.Moreover,based on the theories of rock physics and fracture mechanics,this study establishes micro-fracture development models for both types of source rocks,associated with the calculation of the fracture pressure that is needed for the initiation of fracture development.Furthermore,the relationship between the fluid pressure,fracture pressure,and micro-fracture expansion length during micro-fracture development is quantitatively explored,which helps identify the micro-fracture expansion length.The results indicate that the development of micro-fractures is commonly impacted by the morphology and distribution pattern of the organic matter as well as the mechanical properties of the source rocks.The micro-fractures in turn further affect the hydrocarbon expulsion capacity of the source rocks.The results of this study are expected to provide theoretical and practical guidance for the exploration and exploitation of tight oil and shale oil. | Kaiming Su Jungang Lu Huanxu Zhang Shijia Chen Yong Li Zhenglu Xiao Wen Qiu Meimei Han | 2020 | Geoscience Frontiers2020，11，6： | 1 |
| 6 | One step hot-pressing method for hybrid Li metal anode of solid-state lithium metal batteries显示文摘Safety issues induced by infinite anode volume change and uncontrolled lithium(Li)dendrite growth have become the biggest obstacle to the practical application of Li metal batteries.In addition,the tra-ditional rolling method makes it difficult to manufacture thin Li foil with high mechanical strength and low Li content.Herein,a three-dimensional(3D)lithophilic carbon paper/copper(Cu)current collector hybrid anode with ultra-low Li metal content is prepared by a hot-pressing method.The highly re-versible and stable lithiophilic layer LiC_(x) formed in situ by heating/pressing treatment provides abun-dant nucleation sites and reduces the Li nucleation overpotential,thereby effectively suppressing Li den-drite growth.Moreover,the volume change and pulverization problems of Li metal anode during depo-sition/stripping also can be accommodated by the 3D skeleton.The optimization effect has been directly confirmed by in-situ optical and ex-situ scanning electron microscope observation.Therefore,highly sta-ble performance(158.4 mA h g^(-1) at 2 C after 200 cycles with a capacity retention of 95.24%)in Li@LCP-Cu||NCM811 coin cell can be achieved.Furthermore,the solid-state battery assembled with the hybrid anode,poly(vinylidene fluoride)(PVDF)-based polymer electrolyte and polyethylene oxide(PEO)interface functional layer also exhibits the best electrochemical and safety performance,which also proves that the Li@LCP-Cu anode has great potential for application in solid-state batteries. | Kaiming Wang Yifei Chen Liang Zhang Qihang Zhang Zhi Cheng Yining Su Fei Shen Xiaogang Han | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 7 | Factors controlling the reservoir accumulation of Triassic Chang 6 Member in Jiyuan-Wuqi area,Ordos Basin,NW China显示文摘In the Triassic Yanchang Formation, Jiyuan-Wuqi area, Ordos Basin, the Chang 6 reservoir is contacted to the Chang 7 high-quality source rock, but the oil pools are unevenly distributed, and complex in oil and water distribution. Through cores observation and fracture statistics, combined with comprehensive analyses of physical property, mercury injection, logging and geochemical data, and comparisons of the sandbodies scales, reservoir physical properties, argillaceous laminae and fractures between source and reservoir in the eastern and western oil-bearing areas and in the central water producing area, it is found that the hydrocarbon accumulation patterns are different in the eastern, central and western areas, and the characteristics of hydrocarbon migration under the background of double-provenance were sorted out. The study results show that the crude oil in the eastern area has different Pr/Ph and sterane distribution from that in the western area. The oil and gas primarily migrated vertically. The high-quality source rocks and favorable source-reservoir-cap combinations lay the foundation for large-scale oil and gas accumulations. Vertically, the oil and gas enrichment is controlled by the scale of sandbody and the difference of physical properties, while on the plane, it is controlled by the connectivity of sandbodies, the argillaceous laminae between source rock and reservoir, the reservoir physical property and the fractures. The sandbodies of oil-rich zones in the eastern and western areas have large thickness, low shale content, good physical properties, weak heterogeneity, few argillaceous laminae and abundant fractures, all of which are favorable for the vertical migration and accumulation of oil and gas. In contrast, in the middle area with converging provenances, the reservoirs, composed of thin sandbodies, features rapid variation in lithology and physical properties, strong heterogeneity, poor continuity of sandbodies, abundant argillaceous laminae between source rock and reservoir, and few fractures, makes it difficult for the oil and gas to migrate vertically, and results in low oil enrichment degree ultimately. For the exploration of continental multiple-provenance tight reservoirs, not only the good-property source rocks and reservoirs, but more importantly the source-reservoir contact relationship and the effect of fractures on the hydrocarbon migration and accumulation should be considered. | CHEN Shijia LEI Junjie LIU Chun YAO Jingli LI Yong LI Shixiang SU Kaiming XIAO Zhenglu | 2019 | Petroleum Exploration and Development2019，46，2： | 0 |
| 8 | A Two-dimensional Dual-pore Covalent Organic Framework for Efficient Iodine Capture显示文摘Effectively capturing volatile radioiodine generated during the nuclear fission process is considered to be a safe way to the utilization of nuclear power. Here we report a new two-dimensional covalent organic framework(2D COF), ETTA-PyTTA-COF, as a highly efficient iodine adsorbent, which is constructed through the condensation reaction between 4,4’,4’’,4’’’-(ethene-1,1,2,2-tetrayl)-tetrabenzaldehyde(ETTA) and 1,3,6,8-tetrakis(4-aminophenyl)pyrene(PyTTA). The ETTA-PyTTA-COF possesses a permanent 1D channel porous structure with a high Brunauer-Emmet-Teller(BET) surface area of 1519 m2/g and excellent chemical and thermal stability. It shows ultrahigh iodine adsorption capability, which can reach up to 4.6 g/g in vapor owing to its high BET surface area, large π-conjugated structure and plenty of imine groups in the skeleton of the COF as effective iodine sorption sites. | WEN Zhongliang WANG Shenglin FU Siyao QIAN Jiaying YAN Qianqian XU Huanjun ZUO Kaiming SU Xiaofang ZENG Chaoyuan GAO Yanan | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 9 | Cryo-EM advances in RNA structure determination显示文摘Cryo-electron microscopy(cryo-EM)has emerged as an unprecedented tool to resolve protein structures at atomic resolution.Structural insights of biological samples not accessible by conventional X-ray crystallography and NMR can be explored with cryo-EM because measurements are carried out under near-native crystal-free conditions,and large protein complexes with conformational and compositional heterogeneity are readily resolved.RNA has remained underexplored in cryo-EM,despite its essential role in various biological processes.This review highlights current challenges and recent progress in using cryo-EM singleparticle analysis to determine protein-free RNA structures,enabled by improvement in sample preparation and integration of multiple structural and biochemical methods. | Haiyun Ma Xinyu Jia Kaiming Zhang Zhaoming Su | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
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