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26篇 您的检索式:作者名="Mingxia WU"
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1MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho 2018World Journal of Gastroenterology2018,24,27:29
2SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy.Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun 2019Acta Pharmaceutica Sinica B2019,9,2:18
3Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta.Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin 2022China CDC weekly2022,4,4:7
4MiR-147b inhibits cell viability and promotes apoptosis of rat H9c2 cardiomyocytes via down-regulating KLF13 expression显示文摘最近, microRNAs (miRNAs ) 被显示了在心失败的过程包含。这研究试图在老鼠 H9c2 cardiomyocytes 调查 miR-147b 的功能的角色并且探索内在的分子的机制。H9c2 房间的房间生存能力被 MTT 试金检测。房间 apoptosis 被流动 cytometry 检测。miR-147b 和 KLF13 mRNA 的表示被量的即时 PCR 检测。在 miR-147b 和 KLF13 之间的关系被双酶的记者试金验证。蛋白质层次被西方的污点分析检测。它被发现那 H 2 O 2 禁止了房间生存能力并且以一种集中依赖者方式支持了 H9c2 房间的房间 apoptosis。MiR-147b overexpression miR-147b 压制了房间生存能力并且在 H9c2 房间增加了 apoptosis,当击倒时在 H 2 O 2-treated H9c2 房间。酶记者试金并且在功能的试金显示出的 vitro,那 KLF13 是 miR-147b,和 KLF13 的一个下游的目标在 H9c2 房间的击倒的压制的房间生存能力和导致的 apoptosis。KLF13 的强制表示在 H9c2 房间在房间生存能力和 apoptosis 上恢复了 miR-147b overexpression 的效果。MiR-147b 在 apoptosis 相关的蛋白质上调制了 miR-147b overexpression 的 apoptosis 相关的蛋白质,和效果的表示层次层次被 KLF13 的强制表示在 H9c2 房间阻止。在里面 vivo 实验证明 miR-147b 是起来调整的,并且 KLF13 在从有长期的心失败的老鼠的心肌的纸巾是下面调整的。一起, miR-147b 禁止生存能力并且由在 H9c2 房间指向 KLF13 支持房间 apoptosis,它可以与心失败的致病被联系。Mingxia Gu Jing Wang Yi Wang Yanjuan Xu Yingqiang Zhang Weiqing Wu Shuping Liao 2018Acta Biochimica et Biophysica Sinica2018,50,3:6
5A new species of the genus Crocidura from China based on molecular and morphological data(Eulipotyphla: Soricidae)显示文摘A new species of white-toothed shrew,Crocidura anhuiensis Zhang,Zhang&Li,sp.nov.is described from Mount Huang,China.Genetic sequence(mt DNA Cyt b gene)and morphological(external and skull)data are used to distinguish this newly discovered species.The phylogenetic analysis shows that the materials of this work are monophyletic and allied to C.attenuata by the uncorrected genetic distance 4.9–5.1%,which suggests a species-level divergence.Morphologically,the materials are different from C.attenuata by presenting a greater proportion of tail-to-body ratio and the presence of an obvious tooth root in the mandible.Based on those data,the unnamed species is described as a new species which is currently known only from the Wild Monkey Valley,Mount Huang,Anhui Province,China.Heng Zhang Guiyou Wu Yanqing Wu Jianfei Yao Shuo You Chencheng Wang Feng Cheng Jingjing Chen Mingxia Tang Chunlin Li Baowei Zhang 2019Zoological Systematics2019,44,4:5
6Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy.Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun 2022Acta Pharmaceutica Sinica B2022,12,1:5
7Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis.Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun 2020Journal of Molecular Cell Biology2020,12,4:2
8Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer显示文摘Wei Liu Mingxia Zhai Zongyin Wu Yuanming Qi Yahong Wu Chao Dai Meng Sun Lu Li Yanfeng Gao 2012Amino Acids2012,,:1
9Rapid detection of peste des petits ruminants virus by a reverse transcription loop-mediated isothermal amplification assay显示文摘Lin Li Jingyue Bao Xiaodong Wu Zhiliang Wang Junwei Wang Mingxia Gong Chunju Liu Jinming Li 2010Journal of Virological Methods2010,,1:1
10Identification of serum metabolites enhancing inflammatory responses in COVID-19显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is characterized by a strong production of inflammatory cytokines such as TNF and IL-6,which underlie the severity of the disease.However,the molecular mechanisms responsible for such a strong immune response remains unclear.Here,utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages,we identified that 611 metabolites(of 1,039)were significantly altered in COVID-19 patients.Among them,two metabolites,agmatine and putrescine,were prominently elevated in the serum of patients;and 2-quinolinecarboxylate was changed in a biphasic manner,elevated during early COVID-19 infection but levelled off.When tested in mouse embryonic fibroblasts(MEFs)and macrophages,these 3 metabolites were found to activate the NF-κB pathway that plays a pivotal role in governing cytokine production.Importantly,these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice,but not in the mice lacking NF-κB.Intriguingly,these metabolites have little effects on the activation of interferon regulatory factors(IRFs)for the production of type I interferons(IFNs)for antiviral defenses.These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses,exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons.Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients.Chen-Song Zhang Bingchang Zhang Mengqi Li Xiaoyan Wei Kai Gong Zhiyong Li Xiangyang Yao Jianfeng Wu Cixiong Zhang Mingxia Zhu Lei Zhang Xiufeng Sun Yi-Hong Zhan Zhengye Jiang Wenpeng Zhao Wei Zhong Xinguo Zhuang Dawang Zhou Hai-Long Piao Sheng-Cai Lin Zhanxiang Wang 2022Science China(Life Sciences)2022,65,10:1
11Honeycomb-like polyaniline for flexible and folding all-solid-state supercapacitors显示文摘Porous polyaniline (PANI) was prepared through an efficient and costeffective method by polymerization of aniline in the NaCl solution at room temperature. The resulting PANI provided large surface area due to its highly porous structure and the intercrossed nanorod, resulting in good electrochemical performance. The porous PANI electrodes showed a high specific capacitance of 480 F·g^-1, 3 times greater than that of PANI without using the NaCl solution. We also make chemically crosslinked hydrogel film for hydrogel polymer electrolyte as well as the flexible supercapacitors (SCs) with PANI. The specific capacitance of the device was 234 F·g^-1 at the current density of 1 A·g^-1. The energy density of the device could reach as high as 75 W·h·kg^-1 while the power density was 0.5 kW·kg^-1, indicating that PANI be a promising material in flexible SCs.Ge JU Muhammad Arif KHAN Huiwen ZHENG Zhongxun AN Mingxia WU Hongbin ZHAO Jiaqiang XU Lei ZHANG Salma BILAL Jiujun ZHANG 2019Frontiers of Materials Science2019,13,2:1
12Peony pollen derived nitrogen-doped activated carbon for supercapacitor application显示文摘Peony pollen is a cheap and readily available biomass material with a relatively high protein content.In this work,it was employed as an N-rich precursor to prepare the nitrogen-doped porous carbon for supercapacitor application.The porous carbon microspheres were prepared through a hydrothermal method and subsequent carbonization process.Notably,ammonium borofruoride and potassium hydroxide were employed respectively as an etchant and an activator to modify the porosity of the materials.The as prepared ANPPCs-700 has a super high BET specific surface area of 824.69 m^2/g.The microstructure,chemical state and electrochemical properties of the product were investigated in detail.The prepared nitrogen-doped carbon microspheres exhibits excellent specific capacity of 209 F/g at a current density of lA/g and remained 92.5%of the initial capacitance after 5000 deep cycles at 5 A/g.Yiming Liu Zhongxun An Mingxia Wu Anbao Yuan Hongbin Zhao Jiujun Zhang Jiaqiang Xu 2020Chinese Chemical Letters2020,31,6:1
13Extract of okra lowers blood glucose and serum lipids in high-fat diet induced obese C57BL/6 mice显示文摘Shengjie Fan Yu Zhang Qinhu Sun Lijing Yu Mingxia Li Bin Zheng Ximin Wu Baican Yang Yiming Li Cheng Huang 2014The Journal of Nutritional Biochemistry2014,,:1
14Preparation and properties of polystyrene nanocomposites with graphite ox- ide and graphene as flame retardants 显示文摘Han Yongqin Wu Ying Shen Mingxia 2013Journal of Materi-als Science2013,48,12:1
15Preparation and properties of polystyrene nanocomposites with graphite oxide and graphene as flame retardants显示文摘Yongqin Han Ying Wu Mingxia Shen Xianli Huang Jiajia Zhu Xiaogang Zhang 2013Journal of Materials Science2013,,12:1
16Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection显示文摘The worldwide epidemic of coronavirus disease 2019(COVID-19)is ongoing.Rapid and accurate detection of the causative virus SARSCoV-2 is vital for the treatment and control of COVID-19.In this study,the comparative sensitivity of different respiratory specimen types were retrospectively analyzed using 3,552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC(Center for Disease Control and Prevention).Except for bronchoalveolar lavage fluid(BALF),the sputum possessed the highest positive rate(73.4%–87.5%),followed by nasal swabs(53.1%–85.3%)for both severe and mild cases during the first 14 days after illness onset(d.a.o.).Viral RNA could be detected in all BALF samples collected from the severe group within 14 d.a.o.and lasted up to 46 d.a.o.Moreover,although viral RNA was negative in the upper respiratory samples,it was also positive in BALF samples in most cases from the severe group during treatment.Notably,no viral RNA was detected in BALF samples from the mild group.Despite typical ground-glass opacity observed via computed tomographic scans,no viral RNA was detected in the first three or all upper respiratory tract specimens from some COVID-19 patients.In conclusion,sputum is most sensitive for routine laboratory diagnosis of COVID-19,followed by nasal swabs.Detection of viral RNA in BALF improves diagnostic accuracy in severe COVID-19 patients.Yang Yang Minghui Yang Jing Yuan Fuxiang Wang Zhaoqin Wang Jinxiu Li Mingxia Zhang Jinli Wei Ling Peng Gary Wong Haixia Zheng Weibo Wu Chenguang Shen Mingfeng Liao Kai Feng Jianming Li Qianting Yang Juanjuan Zhao Lei Liu Yingxia Liu 2020The Innovation2020,1,3:1
17Engineering surface oxygen vacancy of mesoporous CeO_(2) nanosheets assembled microspheres for boosting solar-driven photocatalytic performance显示文摘Surface oxygen vacancy defects of mesoporous CeO_(2)nanosheets assembled microspheres(D-CeO_(2))are engineered by polymer precipitation,hydrothermal and surface hydrogenation strategies.The resultant D-CeO_(2)with a main pore diameter of 9.3 nm has a large specific surface area(~102.3 m^(2)/g)and high thermal stability.The mesoporous nanosheets assembled microsphere structure prevents the nanosheets from aggregation,which is beneficial to effective mass transfer and shortens the migration distance of charge carriers.After surface hydrogenation,the photoresponse extends to long wavelength region,combing with the band gap from 2.63 eV reduced to 2.39 eV.Under AM 1.5 G radiation,the photocatalytic degradation rate of tetracycline(TC)can be up to 99.99%,which is three times as high as that of pristine CeO_(2)microspheres.The excellent solar-driven photocatalytic performance can be attributed to the efficient surface oxygen vacancy engineering and the mesoporous nanosheets assembled microsphere structure,which narrows the band gap,shortens the migration distance of carriers,promotes the spatial separation of photogenerated electron-hole pairs and favors mass transfer.The strategy provides new insights for fabricating other high-efficient oxide photocatalysts.Decai Yang Yachao Xu Kai Pan Chuanxin Yu Jiaxing Wu Mingxia Li Fan Yang Yang Qu Wei Zhou 2022Chinese Chemical Letters2022,33,1:0
18Examination of Huntington's disease in a Chinese family显示文摘We report brain imaging and genetic diagnosis in a family from Wuhan,China,with a history of Huntington's disease.Among 17 family members across three generations,four patients(II2,II6,III5,and III9) show typical Huntington's disease,involuntary dance-like movements.Magnetic resonance imaging found lateral ventricular atrophy in three members(II2,II6,and III5).Moreover,genetic analysis identified abnormally amplified CAG sequence repeats(> 40) in two members(III5 and III9).Among borderline cases,with clinical symptoms and brain imaging features of Huntington's disease,two cases were identified(II2 and II6),but shown by mutation analysis for CAG expansions in the important transcript 15 gene,to be non-Huntington's disease.Our findings suggest that clinical diagnosis of Huntington's disease requires a combination of clinical symptoms,radiological changes,and genetic diagnosis.Mingxia Yu Xiaogai Li Sanyun Wu Ji Shen Jiancheng Tu 2014Neural Regeneration Research2014,9,4:0
19High-loading, ultrafine Ni nanoparticles dispersed on porous hollow carbon nanospheres for fast (de)hydrogenation kinetics of MgH_(2)显示文摘Magnesium hydride(MgH2) is one of the most promising hydrogen storage materials for practical application due to its favorable reversibility, low cost and environmental benign;however, it suffers from high dehydrogenation temperature and slow sorption kinetics.Exploring proper catalysts with high and sustainable activity is extremely desired for substantially improving the hydrogen storage properties of MgH2. In this work, a composite catalyst with high-loading of ultrafine Ni nanoparticles(NPs) uniformly dispersed on porous hollow carbon nanospheres is developed, which shows superior catalytic activity towards the de-/hydrogenation of MgH2. With an addition of 5wt% of the composite, which contains 90 wt% Ni NPs, the onset and peak dehydrogenation temperatures of MgH2are lowered to 190 and 242 ℃, respectively. 6.2 wt% H2is rapidly released within 30 min at 250 ℃. The amount of H2that the dehydrogenation product can absorb at a low temperature of 150 ℃ in only 250 s is very close to the initial dehydrogenation value. A dehydrogenation capacity of 6.4wt% remains after 50 cycles at a moderate cyclic regime, corresponding to a capacity retention of 94.1%. The Ni NPs are highly active,reacting with MgH2and forming nanosized Mg2Ni/Mg2NiH4. They act as catalysts during hydrogen sorption cycling, and maintain a high dispersibility with the help of the dispersive role of the carbon substrate, leading to sustainably catalytic activity. The present work provides new insight into designing stable and highly active catalysts for promoting the(de)hydrogenation kinetics of MgH2.Shun Wang Mingxia Gao Zhihao Yao Kaicheng Xian Meihong Wu Yongfeng Liu Wenping Sun Hongge Pan 2022Journal of Magnesium and Alloys2022,10,12:0
20Effect of Electromagnetic Compound Treatment on Microstructure and Performance of Cemented Carbide显示文摘In order to study the effect of electromagnetic compound treatment on the mechanical property, cutting performance and microstructure of cemented carbide, the samples were treated by a self-made electromagnetic compound treatment device with different magnetic field strength(H=1, 1.25 and 1.5 T). The electromagnetic compound treatment method was proposed to couple pulsed magnetic field and pulsed current. The results show that after the pulsed magnetic field treatment, the values of the transverse rupture strength of the samples were respectively reduced by 21%, 20.6% and 20.1%;the cutting performance was decreased by about 4.5%, which means the tool life was decreased. After the electromagnetic compound treatment, the values of the transverse rupture strength of the rectangular samples were respectively increased by 8%, 8.6% and 9.5%, and the tool life was increased by 4.2%, 7% and 10.3%. After the electromagnetic compound treatment, the pulse current provided the driving force for dislocation motion. A strong pulse current driving force is more likely to make the dislocation multiply and slip. A high density dislocation cell is formed within the material, so the mechanical properties were significantly increased.韦辽 杨屹 YANG Gang WU Mingxia WEI Can WU Xiuli 2019Journal of Wuhan University of Technology(Materials Science)2019,34,5:0
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