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| 1 | HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice显示文摘HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2 status is mandatory, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs such as Trastuzumab. This manuscript focuses on HER2 in gastric carcinogenesis, on optimal evaluation of HER2 and on the possible causes which may contribute to inaccurate HER2 evaluation. Similarly to breast cancer HER2 evaluation, standardization of HER2 testing in gastric cancer is necessary in diagnostic practice. The three principle aspects which require consideration are:(1) the choice of sample with regards to cancer morphology- intestinal vs diffuse areas;(2) the choice of scoring criteria- use of HER2 scoring criteria specific for gastric cancer; and(3) the choice of HER2 evaluation methods- use of an algorithm in which both immunohistochemistry and in situ hybridization play a role. Problematic issues include:(1) pre-analytic variables with particular emphasis on fixation;(2) recommended methodology for HER2 assessment(immunohistochemistry vs in situ hybridization);(3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases;(4) reliability of biopsies in HER 2 evaluation; and(5) quantity of sample(FFPE blocks from surgical specimens or endoscopic biopsies) necessary for an adequate assessment. | Federica Grillo Matteo Fassan Francesca Sarocchi Roberto Fiocca Luca Mastracci | 2016 | World Journal of Gastroenterology2016，22，26： | 3 |
| 2 | Intracellular, Intercellular, and Stromal Invasion of Gastric Mucosa, Preneoplastic Lesions, and Cancer by Helicobacter pylori显示文摘 | Vittorio Necchi Maria Elena Candusso Francesca Tava Ombretta Luinetti Ulderico Ventura Roberto Fiocca Vittorio Ricci Enrico Solcia | 2007 | Gastroenterology2007，，3： | 2 |
| 3 | The contribution of cell phenotype to the behavior of gastric cancer显示文摘 | Enrico Solcia Catherine Klersy Alessandro Vanoli Federica Grillo Rachele Manca Francesca Tava Ombretta Luinetti Roberto Fiocca | 2013 | Gastric Cancer2013，，4： | 1 |
| 4 | Early HER2 dysregulation in gastric and oesophageal carcinogenesis显示文摘 | Matteo Fassan Luca Mastracci Federica Grillo Vittorina Zagonel Sara Bruno Giorgio Battaglia Francesca Pitto Donato Nitti Tiziana Celiento Giovanni Zaninotto Roberto Fiocca Massimo Rugge | 2012 | Histopathology2012，，5： | 1 |
| 5 | Microscopic esophagitis in gastro-esophageal reflux disease: individual lesions, biopsy sampling, and clinical correlations显示文摘 | Luca Mastracci Paola Spaggiari Federica Grillo Patrizia Zentilin Pietro Dulbecco Paola Ceppa Paola Baccini Carlo Mansi Vincenzo Savarino Roberto Fiocca | 2009 | Virchows Archiv2009，，1： | 1 |
| 6 | Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn显示文摘 | Edoardo Savarino Patrizia Zentilin Luca Mastracci Pietro Dulbecco Elisa Marabotto Lorenzo Gemignani Luca Bruzzone Nicola Bortoli Anna Chiara Frigo Roberto Fiocca Vincenzo Savarino | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 7 | Heterogeneous Her2/Neu expression in gastric and gastroesophageal cancer显示文摘 | Federica Grillo Matteo Fassan Roberto Fiocca Luca Mastracci | 2015 | Human Pathology2015，，： | 1 |
| 8 | Minimum biopsy set for HER2 evaluation in gastric and gastro-esophageal junction cancer显示文摘 | Irene Gullo Federica Grillo Luca Molinaro Matteo Fassan Annalisa De Silvestri Carmine Tinelli Massimo Rugge Roberto Fiocca Luca Mastracci | 2015 | EIO2015，，： | 1 |
| 9 | The Reliability of Endoscopic Biopsies in Assessing HER2 Status in Gastric and Gastroesophageal Junction Cancer: A Study Comparing Biopsies with Surgical Samples显示文摘 | Federica Grillo Matteo Fassan Chiara Ceccaroli Cinzia Giacometti Monica Curto Vittorina Zagonel Paola Ceppa Donato Nitti Carlo Castoro Roberto Fiocca Massimo Rugge Luca Mastracci | 2013 | Translational Oncology2013，，1： | 1 |
| 10 | Long-term endoscopic surveillance of patients with Barrett’s esophagus. incidence of dysplasia and adenocarcinoma: a prospective study显示文摘 | Massimo Conio Sabrina Blanchi Gabriella Lapertosa Roberto Ferraris Renato Sablich Santino Marchi Vittorio D’Onofrio Teresa Lacchin Gaetano Iaquinto Guido Missale Paolo Ravelli Renzo Cestari Giorgio Benedetti Giuseppe Macrì Roberto Fiocca Francesco Munizzi | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 11 | Achalasia With Dense Eosinophilic Infiltrate Responds to Steroid Therapy显示文摘 | Edoardo Savarino Lorenzo Gemignani Patrizia Zentilin Nicola De Bortoli Alberto Malesci Luca Mastracci Roberto Fiocca Vincenzo Savarino | 2011 | Clinical Gastroenterology and Hepatology2011，，： | 1 |
| 12 | Long-term endoscopic surveillance of patients with Barrett’s esophagus. incidence of dysplasia and adenocarcinoma: a prospective study显示文摘 | Massimo Conio Sabrina Blanchi Gabriella Lapertosa Roberto Ferraris Renato Sablich Santino Marchi Vittorio D’Onofrio Teresa Lacchin Gaetano Iaquinto Guido Missale Paolo Ravelli Renzo Cestari Giorgio Benedetti Giuseppe Macrì Roberto Fiocca Francesco Munizzi | 2003 | The American Journal of Gastroenterology2003，，： | 1 |
| 13 | Pancreatic metastasis from mycosis fungoides mimicking primary pancreatic tumor显示文摘Mycosis fungoides(MF) is a cutaneous T-cell lymphoma that can undergo local progression with possible systemic dissemination. We report a case of a patient affected by MF with a pancreatic mass that was a diagnostic challenge between primitive tumor and pancreatic metastasis from MF. Clinical setting findings and imaging studies raised the suspicion of a pancreatic primary neoplasm. A diagnostic clue was provided by the combined histomorphologic/immunohistochemical study of pancreatic and cutaneous biopsies, which revealed a pancreatic localization of MF. Considering the rarity of metastatic localization of MF to the pancreas, we next investigated whether chemokinechemokine receptor interactions could be involved in the phenomenon to provide new insight into the possible mechanisms underlying metastatic localization of MF to the pancreas. Histological analyses of archival pancreatic tissue demonstrated that glucagon-secreting cells of the pancreatic islets expressed the CCL27 chemokine, which may have attracted in our case metastatic MF cells expressing the complementary receptor CCR10. | Paola Ceriolo Valentina Fausti Elisa Cinotti Silvia Bonadio Lizzia Raffaghello Giovanna Bianchi Giulio Fraternali Orcioni Roberto Fiocca Franco Rongioletti Vito Pistoia Giacomo Borgonovo | 2016 | World Journal of Gastroenterology2016，22，12： | 0 |
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