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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China显示文摘The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (<500), Ce/Yb (<15) and SiO2 (43-55%), and relatively high Fe2O3T (6.4-11.5%); (2) the high-Ti/Y type situated in the western Tianshan area, which has high Ti/Y (>500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, εNd(t) ≈ +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick lithosphere and low geothermal gradient. | XIA Linqi, XU Xueyi, XIA Zuchun, LI Xiangmin, MA Zhongping and WANG Lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@pub.xaonline.com. Liu Shuchun and Liu Xinzhu | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 49 |
| 4 | Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design study of neuropsychology and functional magnetic resonance imaging显示文摘When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527). | Wen-Li Chen Qian Ye Si-Cong Zhang Yang Xia Xi Yang Ti-Fei Yuan Chun-Lei Shan Jian-An Li | 2019 | Neural Regeneration Research2019，14，6： | 28 |
| 5 | Discovery of Late Cretaceous foraminifera in the Songliao Basin: Evidence from SK-1 and implications for identifying seawater incursions显示文摘The Songliao Basin is the largest oil-bearing basin in China.In the absence of sufficient evidence,the possibility of seawater incursion(s) into the Songliao Basin remains controversial.Recently,we discovered relatively abundant foraminifera fossils from units 1 and 2 of the Nenjiang Formation of borehole SK-1.Benthic foraminifera (Gavlinella sp.,Anomalinoides sp.,Pullenia sp.,Haplophragmoides sp.,Karrorulina hokkaidoana,Clavulinoides sp.),as well as planktonic foraminifera (Archaeoglobigerina blowi,Archaeoglobigerina cretacea and Hedbergella flandrini),were identified.These fossils were widely distributed in the marine Cretaceous.According to the global distribution of the above-mentioned planktonic foraminifera,the age of these fossil bearing strata appears to be Late Coniacian to Santonian.More importantly,these foraminifera provide direct evidence for marine water incursions into the Songliao Basin during deposition of the Lower Nenjiang Formation. | XI DangPeng WAN XiaoQiao FENG ZhiQiang LI Shun FENG ZiHui JIA JianZhong JING Xia SI WeiMin | 2011 | Chinese Science Bulletin2011，56，3： | 21 |
| 6 | Ecological response to the climate change on the northern slope of the Tianshan Mountains in Xinjiang显示文摘The Tianshan Mountains is a high and huge mountain body lying across the central part of Xinjiang, China, and is also the main area where the runoff forms in Xinjiang. In this paper, a set of RS-based study methods is put forward for deriving the information about the natural change of the ecology in arid areas, and the relationship between the climate change trend and the corresponding ecological response on the northern slope of the Tianshan Mountains since recent 40 years is analyzed from the scales of the land cover ecosystems and landscapes based on the observed data of climate, hydrology, modern glaciers and lakes on the northern slopes of the Tianshan Mountains since recent 40 years and the satellite RS data since recent 10 years by using the RS and GIS technologies. The results are as follows: (1) The overall trend of climate change on the northern slope of the Tianshan Mountains since recent 40 years is that both air temperature and precipitation are increased, especially the increase amplitudes of air tempera-ture, precipitation and annual runoff volume are high since the decade of the 1990s; (2) the in-tegrated indexes of the vegetation in all the geographical divisions on the northern slope of the Tianshan Mountains are obviously increased since recent 10 years, especially in the artificial oases and the foothill belts, such a change trend is advantageous for improving the vegetation ecology; and (3) the vegetation ecology in the arid areas is extremely sensitive to the climate change, the vegetation coverage and the biomass on the northern slope of the Tianshan Moun-tains are continuously increased because of the climate change since recent 10 years, their in-crease amplitudes in the plains and during the late stage are obviously higher than that in the mountainous regions and during the early stage. | CHEN Xi1, LUO Geping1, XIA Jun2, ZHOU Kefa1, LOU Shaoping3 & YE Minquan4 1. Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China 2. Institute of Geographical and Resources Sciences, Chinese Academy of Sciences, Beijing 100101, China 3. Urumqi Meteorological-satellite Land Station, Urumqi 830011, China 4. Seismological Bureau of Xinjiang Uygur Autonomous Region, Urümqi 830011, China Correspondence should be addressed to Chen Xi | 2005 | Science China Earth Sciences2005，48，6： | 19 |
| 7 | Contrast-enhanced ultrasound in diagnosis of gallbladder adenoma显示文摘BACKGROUND:Gallbladder adenoma is a pre-cancerous neoplasm and needs surgical resection.It is difficult to differentiate adenoma from other gallbladder polyps using imaging examinations.The study aimed to illustrate characteristics of contrast-enhanced ultrasound(CEUS)and its diagnostic value in gallbladder adenoma. | Hai-Xia Yuan Jia-Ying Cao Wen-Tao Kong Han-Sheng Xia Xi Wang Wen-Ping Wang | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 17 |
| 8 | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components显示文摘AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters. | Han-Lin Gong Wen-Fu Tang Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang | 2009 | World Journal of Gastroenterology2009，15，47： | 16 |
| 9 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 10 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 11 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 12 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 13 | Geochemistry of the subduction-related magmatic rocks in the Dahong Mountains, northern Hubei Province--Constraint on the existence and subduction of the eastern Mianlüe oceanic basin显示文摘The existence and subduction of the eastern Mianl黣 oceanic basin in the south Qinling belt are keys to understand the Qinling orogen. Based on geological mapping, several volcanic slices have been identified in Tumen, Zhoujiawan, Xiaofu and Yuantan areas, which distribute in the northern margin of the Dahong Mountains (DHM), and thrust into the Sanli-gang-Sanyang fault. These slices consist mainly of diabases, basaltic-andesitic lavas, pyroclastic rocks and a minor tuff. The geochemistry of the basalts, andesites,and diabases is characterized by depleting in Nb and Ta, enriching in Th and LILE (e.g.K, Rb, Ba), and undifferentiating in HFSE. These geochemical characteristics suggest that the original magma of these rocks was derived from a mantle wedge above a subduction zone, and formed in an island-arc setting in Carboniferous-early Triassic. Comparing with the ophiolites and island-arc volcanic rocks in Mianxian-Leyang area to the west, it is reasonable to consider that there had been an oceanic basin connecting with the Mianle ancient ocean to the westward, distributing along the south edge of the Tongbai-Dabie block. In view of the ophiolite in Huashan area and these island-arc volcanic rocks along the north of the Dahong Mountains, it is suggested that there had been a plate tectonic evolutionary history with oceanic basin rifting and subduction in this region. | DONG Yunpeng, ZHANG Guowei, ZHAO Xia, YAO Anping & LIU Xiaoming The Key Laboratory of Continental Dynamics, Ministry of Education, Department of Geology, Northwest University, Xi抋n 710069,China | 2004 | Science China Earth Sciences2004，47，4： | 12 |
| 14 | Synthesis of CuO nanometer powder by one step solid state reaction at room temperature显示文摘Copper oxide nanometer powder was synthesized by one step solid state reaction of CuCl-2·2H-2O with NaOH at room temperature. The solid product CuO was characterized by X-ray diffraction and a transmission electron microscope. It has been found that the particles of prepared copper oxide are spherical with average diameter of 20 nm. This new method has the advantages of convenience and high yield compared with literature methods. | Dianzeng Jia Jianqun Yu Xi Xia | 1998 | Chinese Science Bulletin1998，43，7： | 11 |
| 15 | Late Cretaceous palynology and paleoclimate change:Evidence from the SK1(South) core, Songliao Basin, NE China显示文摘Cretaceous climate was warmer than today.The Songliao Basin contains one of the most important Late Cretaceous non-marine deposits in China for the research of the paleoenvironment and paleoclimate.This research is based on core samples from the SK1(S)borehole.The strata sampled are the upper part of the Quantou Formation to member 2 of the Nenjiang Formation,where spores,pollen,dinoflagellates,and other microfossils are abundantly preserved.Based on analysis of the spores and pollen fossils from the core samples,the following six fossil assemblage zones have been recognized in ascending order:The Cicatricosisporites-Cyathidites-Pinuspollenites,Schizaeoisporites-Cyathidites-Classopollis,Cyathidites-Schizaeoisporites,Schizaeoisporites-Cyathidites-Proteacidites,Proteacidites-Cyathidites-Dictyotriletes,and the Lythraites-Callistipollenites-Schizaeoisporites zones.The six fossil zones range from the late Cenomanian to early Campanian.The Late Cretaceous dinoflagellate cysts in the Songliao Basin are of high abundance and low diversity.Specific phytoplankton types reflect salinity changes of the Songliao Lake.Paleoecology of the dinoflagellates suggests that sediments of members 2 and 3 of the Yaojia Formation(K2y2+3)were deposited in a freshwater environment,whereas members 2 and 3 of the Qingshankou Formation(K2q2+3)and members 1 and 2 of the Nenjiang Formation(K2n1+2)were deposited in freshwater to brackish water environments.Combined with the paleoecology of dinoflagellates and the palynomorph biozones,valuable information of the paleoclimate was provided.The quantitative analyses of spores and pollen fossils,such as vegetation type,climate type,and humidity type,diversity and dominance,indicate a relatively sub-humid,mid-subtropical paleoclimate,with slight climatic fluctuation and/or temporal change. | ZHAO Jing WAN XiaoQiao XI DangPeng JING Xia LI Wei HUANG QingHua ZHANG JinYan | 2014 | Science China Earth Sciences2014，57，12： | 10 |
| 16 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 17 | Comparison of Xpert MTB/RIF, Real Amp, and CPA Tests in Detecting Mycobacterium tuberculosis显示文摘Today, tuberculosis (TB) remains a global public health threat associated with significantly high rates of morbidity and mortality. The World Health Organization's (WHO) Global Tuberculosis Report 2018[1] has reported that in 2017, 10.0 million people across the world had developed TB diseases that resulted in an estimated 1.6 million deaths, and 889, 000 people developed TB in China that led to 39, 000 TB-related deaths. Therefore, rapid and accurate detection of Mycobacterium tuberculosis (MTB) is important for initiating early treatment and reducing mortality. Traditional diagnostic methods for pulmonary TB incorporate chest radiography and sputum smear microscopy;however, several cases of tuberculosis go undiagnosed because of the low sensitivity of smear microscopy[2]. | OU Xi Chao LI Hui LIU Dong Xin XIA Hui MA Xiao Guang WANG Shao Hua WANG Sheng Fen ZHU Yan Kun ZHAO Bing ZHAO Yan Lin | 2019 | Biomedical and Environmental Sciences2019，32，3： | 9 |
| 18 | Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats显示文摘Background:Cardiac remodeling after acute myocardial infarction(AMI)is an important process.The present study aimed to assess the protective effects of astaxanthin(ASX)on cardiac remodeling after AMI.Methods:The study was conducted between April and September 2018.To create a rat AMI model,rats were anesthetized,and the left anterior descending coronary artery was ligated.The rats in the ASX group received 10 mg·kg-1·day-1 ASX by gavage for 28 days.On the 1st day after AMI,but before ASX administration,six rats from each group were sacrificed to evaluate changes in the heart function and peripheral blood(PB)levels of inflammatory factors.On the 7th day after AMI,eight rats from each group were sacrificed to evaluate the PB levels of inflammatory factors and the M2 macrophage count using both immunofluorescence(IF)and flow cytometry(FC).The remaining rats were observed for 28 days.Cardiac function was examined using echocardiography.The inflammatory factors,namely,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and IL-10,were assessed using enzyme-linked immunosorbent assay.The heart weight/body weight(BW),and lung weight(LW)/BW ratios were calculated,and myocardial fibrosis in the form of collagen volume fraction was measured using Masson trichrome staining.Hematoxylin and eosin(H&E)staining was used to determine the myocardial infarct size(MIS),and TdT-mediated dUTP nick-end labeling staining was used to analyze the myocardial apoptosis index.The levels of apoptosis-related protein,type I/III collagen,transforming growth factorβ1(TGF-β1),metalloproteinase 9(MMP9),and caspase 3 were assessed by Western blotting.Unpaired t-test,one-way analysis of variance,and non-parametric Mann-Whitney test were used to analyze the data.Results:On day 1,cardiac function was worse in the ASX group than in the sham group(left ventricular end-systolic diameter[LVIDs]:0.72±0.08 vs.0.22±0.06 cm,t=-11.38;left ventricular end-diastolic diameter[LVIDd]:0.89±0.09 vs.0.48±0.05 cm,t=-9.42;end-systolic volume[ESV]:0.80[0.62,0.94]vs.0.04[0.03,0.05]mL,Z=-2.89;end-diastolic volume[EDV]:1.39[1.03,1.49]vs.0.28[0.22,0.32]mL,Z=-2.88;ejection fraction[EF]:0.40±0.04 vs.0.86±0.05,t=10.00;left ventricular fractional shortening[FS]rate:0.19[0.18,0.20]%FS vs.0.51[0.44,0.58]%FS,Z=-2.88,all P<0.01;n=6).The levels of inflammatory factors significantly increased(TNF-α:197.60[133.89,237.94]vs.50.48[47.2157.10]pg/mL,Z=-2.88;IL-1β:175.23[160.74,215.09]vs.17.78[16.83,19.56]pg/mL,Z=-2.88;IL-10:67.64[58.90,71.46]vs.12.33[11.64,13.98]pg/mL,Z=-2.88,all P<0.01;n=6).On day 7,the levels of TNF-αand IL-1βwere markedly lower in the ASX group than in the AMI group(TNF-α:71.70[68.60,76.00]vs.118.07[106.92,169.08]pg/mL,F=42.64;IL-1β:59.90[50.83,73.78]vs.151.60[108.4,198.36]pg/mL,F=44.35,all P<0.01,n=8).Conversely,IL-10 levels significantly increased(141.84[118.98,158.36]vs.52.96[42.68,74.52]pg/mL,F=126.67,P<0.01,n=8).The M2 macrophage count significantly increased(2891.42±211.29 vs.1583.38±162.22,F=274.35,P<0.01 by immunofluorescence test;0.96±0.18 vs.0.36±0.05,F=46.24,P<0.05 by flowcytometry test).On day 28,cardiac function was better in the ASX group than in the AMI group(LVIDs:0.50[0.41,0.56]vs.0.64[0.56,0.74]cm,Z=-3.60;LVIDd:0.70[0.60,0.76]vs.0.80[0.740.88]cm,Z=-2.96;ESV:0.24[0.18,0.45]vs.0.58[0.44,0.89]mL,Z=-3.62;EDV:0.76[0.44,1.04]vs.1.25[0.82,1.46]mL,Z=-2.54;EF:0.60±0.08 vs.0.50±0.12,F=160.48;%FS:0.29[0.24,0.31]vs.0.20[0.17,0.21],Z=-4.43,all P<0.01;n=16).The MIS and LW/BW ratio were markedly lower in the ASX group than in the AMI group(myocardial infarct size:32.50±1.37 vs.50.90±1.73,t=23.63,P<0.01,n=8;LW/BW:1.81±0.15 vs.2.17±0.37,t=3.66,P=0.01,n=16).The CVF was significantly lower in the ASX group than in the AMI group:12.88±2.53 vs.28.92±3.31,t=10.89,P<0.01,n=8.The expression of caspase 3,TGF-β1,MMP9,and type I/III collagen was lower in the ASX group than in the AMI group(caspase 3:0.38±0.06 vs.0.66±0.04,t=8.28;TGF-β1:0.37±0.04 vs.0.62±0.07,t=6.39;MMP9:0.20±0.06 vs.0.40±0.06,t=4.62;type I collagen:0.42±0.09 vs.0.74±0.07,t=5.73;type III collagen:0.13±0.02 vs.0.74±0.07,t=4.32,all P<0.01;n=4).Conclusions:ASX treatment after AMI may promote M2 macrophages and effectively attenuate cardiac remodeling by inhibiting inflammation and reducing myocardial fibrosis. | Xia Pan Kai Zhang Cheng Shen Xi Wang Long Wang Ya-Yi Huang | 2020 | Chinese Medical Journal2020，，15： | 8 |
| 19 | Recent advances in prevention of hepatitis B recurrence after liver transplantation显示文摘Liver transplantation is the only effective treatment for hepatitis B virus(HBV)-related end-stage liver disease.However,without antiviral prophylaxis,the recurrence rate of hepatitis B is as high as 80%-100%,which leads to a 50% mortality rate in the first 2 years after liver transplantation.Combination therapy of hepatitis B immunoglobulin(HBIG) and lamivudine demonstrated a higher efficacy of prophylaxis and further reduced the rate of recurrence to < 10%.The strategy of HBIG combined with lamivudine has been the standard treatment in many centers.However,the high rate of lamivudine resistance and the many disadvantages of HBIG have compelled surgeons to reconsider the longterm efficacy of this strategy for the prevention of HBV reinfection.Recently,new nucleos(t)ide analogues,such as entecavir and tenofovir,have been approved as first-line monotherapies for the treatment of chronic hepatitis B infection.These antiviral medicines have replaced lamivudine as the first choice in the prevention of HBV recurrence after liver transplantation.Various therapies that are composed of entecavir,tenofovir,and lamivudine plus adefovir,with or without HBIG have been adopted in several liver transplant centers.This article reviews the recent advances in prophylaxis for the recurrence of hepatitis B after liver transplantation. | Zhi-Feng Xi Qiang Xia | 2015 | World Journal of Gastroenterology2015，21，3： | 8 |
| 20 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
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