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| 1 | Clinical outcomes of ampullary neoplasms in resected margin positive or uncertain cases after endoscopic papillectomy显示文摘BACKGROUND Endoscopic papillectomy(EP) for benign ampullary neoplasms could be a lessinvasive alternative to pancreatoduodenectomy(PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. The clinical outcomes of resected margin positive or uncertain cases after EP remain unknown.AIM To investigate the clinical outcomes of resected margin positive or uncertain cases after EP.METHODS Between January 2007 and October 2018, all patients with ampullary tumors who underwent EP at Kobe University Hospital were included in this study. The indications for EP were as follows: adenoma, as determined by preoperative endoscopic biopsy, without bile/pancreatic duct extension, according to endoscopic ultrasound or intraductal ultrasound. The clinical outcomes of resected margin positive or uncertain cases after EP were retrospectively investigated.RESULTS Of the 45 patients, 29 were male, and 16 were female. The mean age of the patients was 65 years old. Forty-one patients(89.5%) underwent en bloc resection,and 4 patients(10.5%) underwent piecemeal resection. After EP, 33 tumors were histopathologically diagnosed as adenoma, and 12 were diagnosed as adenocarcinoma. The resected margins were positive or uncertain in 24 patients(53.3%). Of these cases, 15 and 9 were diagnosed as adenoma and adenocarcinoma, respectively. Follow-up observation was selected for all adenomas and 5 adenocarcinomas. In the remaining 4 adenocarcinoma cases,additional PD was performed. Additional PD was performed in 4 cases, and residual carcinoma was found after the additional PD in 1 of these cases. In the follow-up period, local tumor recurrence was detected in 3 cases. Two of these cases involved primary EP-diagnosed adenoma. The recurrent tumors were also adenomas detected by biopsy. The remaining case involved primary EPdiagnosed adenocarcinoma. The recurrent tumor was also an adenocarcinoma.All of the recurrent tumors were successfully treated with argon plasma coagulation(APC). There was no local or lymph node recurrence after the APC.The post-APC follow-up periods lasted for 57.1 to 133.8 mo. No ampullary tumor-related deaths occurred in all patients.CONCLUSION Resected margin positive or uncertain cases after EP could be managed by endoscopic treatment including APC, even in cases of adenocarcinoma. EP could become an effective less-invasive first-line treatment for early stage ampullary tumors. | Arata Sakai Masahiro Tsujimae Atsuhiro Masuda Takao Iemoto Shigeto Ashina Kohei Yamakawa Takeshi Tanaka Shunta Tanaka Yasutaka Yamada Ryota Nakano Yu Sato Manabu Kurosawa Takuya Ikegawa Seiji Fujigaki Takashi Kobayashi Hideyuki Shiomi Yoshifumi Arisaka Tomoo Itoh Yuzo Kodama | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Hybrid Rubisco with Complete Replacement of Rice Rubisco Small Subunits by Sorghum Counterparts Confers C4 Plant-like High Catalytic Activity显示文摘Photosynthetic rate at the present atmospheric condition is limited by the CO2-fixing enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)because of its extremely low catalytic rate(kcat)and poor affinity for C02(Kc)and specificity for CO2(Sc/O).Rubisco in C4 plants generally shows higher k cat than that in C3 plants.Rubisco consists of eight large subunits and eight small subunits(RbcS).Previously,the chimeric incorporation of sorghum C4-type RbcS significantly increased the k cat of Rubisco in a C3 plant,rice.In this study,we knocked out rice RbcS multigene family using the CRISPR-Cas9 technology and completely replaced rice RbcS with sorghum RbcS in rice Rubisco.Obtained hybrid Rubisco showed almost C4 plant-like catalytic properties,i.e.,higher kcai,higher Kc,and lower Sc/O.Transgenic lines expressing the hybrid Rubisco accumulated reduced levels of Rubisco,whereas they showed slightly but significantly higher photosynthetic capacity and similar biomass production under high C 02 condition compared with wild-type rice.High-resolution crystal structural analysis of the wild-type Rubisco and hybrid Rubisco revealed the structural differences around the central pore of Rubisco and the pC-pD hairpin in RbcS.We propose that such differences,particularly in the pC-pD hairpin,may impact the flexibility of Rubisco catalytic site and change its catalytic properties. | Hiroyoshi Matsumura Keita Shiomi Akito Yamamoto Yuri Taketani Noriyuki Kobayashi Takuya Yoshizawa Shun-ichi Tanaka Hiroki Yoshikawa Masaki Endo Hiroshi Fukayama | 2020 | Molecular Plant2020，13，11： | 8 |
| 3 | Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer显示文摘瞄准:在早胰腺的致癌作用期间调查遇见 c 的表示。方法:我们使用了 46 体积纸巾和 36 件微把样品,包括正常的胰,慢性胰炎,和胰腺的癌症,为量的即时反向的抄写聚合酶链反应。结果:大批,组织分析,胰腺的癌症纸巾显著地表示了高水平比遇见 c 做了慢性胰炎和正常的胰纸巾。遇见 c 的层次没在慢性胰炎和正常的胰纸巾之间不同。在基于 microdissection 的分析,遇见 c 比在正常管的上皮细胞在微把的胰腺的癌症房间和影响胰腺炎的上皮细胞在高水平被表示(两, P <
0.01 ) 。有趣地,影响胰腺炎的上皮细胞表示了层次遇见 c 类似于那些胰腺的癌症房间。结论:Overexpression 遇见 c 在胰腺的致癌作用的早阶段期间发生,并且遇见 c 的表示的单个改变不为到胰腺的癌症房间的长期的影响胰腺炎的上皮细胞的前进是足够的。 | Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro Ogura Daisuke Yamada Takuya Egami Hayato Fujita Seiji Ohashi Eishi Nagai Masao Tanaka | 2006 | World Journal of Gastroenterology2006，12，24： | 4 |
| 4 | Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study显示文摘BACKGROUND Double-balloon endoscopic retrograde cholangiography (DB-ERC) is widely performed for biliary diseases after reconstruction in gastrointestinal surgery,but there are few reports on DB-ERC after hepatectomy or living donor liver transplantation (LDLT).AIM To examine the success rates and safety of DB-ERC after hepatectomy or LDLT METHODS The study was performed retrospectively in 26 patients (45 procedures) who underwent hepatectomy or LDLT (liver operation:LO group) and 40 control patients (59 procedures) who underwent pancreatoduodenectomy (control group).The technical success (endoscope reaching the choledochojejunostomy site),diagnostic success (performance of cholangiography),therapeutic success(completed interventions) and overall success rates,insertion and procedure(completion of DB-ERC) time,and adverse events were compared between these groups.RESULTS There were no significant differences between LO and control groups in the technical [93.3%(42/45) vs 96.6%(57/59),P=0.439],diagnostic [83.3%(35/42) vs83.6%(46/55),P=0.968],therapeutic [97.0%(32/33) vs 97.7%(43/44),P=0.836],and overall [75.6%(34/45) vs 79.7%(47/59),P=0.617] success rates.The median insertion time (22 vs 14 min,P <0.001) and procedure time (43.5 vs 30 min,P=0.033) were significantly longer in the LO group.The incidence of adverse events showed no significant difference [11.1%(5/45) vs 6.8%(4/59),P=0.670].CONCLUSION DB-ERC after liver operation is safe and useful but longer time is required,so should be performed with particular care. | Ryo Nishio Hiroki Kawashima Masanao Nakamura Eizaburo Ohno Takuya Ishikawa Takeshi Yamamura Keiko Maeda Tsunaki Sawada Hiroyuki Tanaka Daisuke Sakai Ryoji Miyahara Masatoshi Ishigami Yoshiki Hirooka Mitsuhiro Fujishiro | 2020 | World Journal of Gastroenterology2020，26，10： | 3 |
| 5 | Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration显示文摘在生长因素刺激之上,支架蛋白质, Gab1,是酷氨酸 phosphorylated 并且随后适配器蛋白质, Crk,从 Gab1 播送信号。我们以前证明了没有细胞外的刺激, Crk overexpression,在各种各样的人的癌症可检测,导致 Gab1 的酷氨酸 phosphorylation。在现在的学习,内在的机制进一步被调查。CrkII 的 Mutational 分析证明 SH2 领域,然而并非 SH3 (N) 或 CrkII 的规章的 Y221 残余,为 Gab1-Y307 phosphorylation 的正式就职是批评的。CrkII 的 SH2 变化也减少了和 Gab1 的相互作用。在 GST 下拉试金,而 Crk-SH3 (N) 与 Gab1 异种交往了, Crk-SH2 跳了到野类型的 Gab1,它缺乏聚类的酷氨酸区域(残余 242-410 ) 。Gab1 的酷氨酸 phosphorylation 被表明适配器的所有 Crk 家庭蛋白质,然而并非另外的包含 SH2 导致。Src 家庭 kinase 禁止者, PP2,废除 Gab1 的导致 Crk 的酷氨酸 phosphorylations。Y307 phosphorylation 在缺乏 Src,是,和 Fyn 的成纤维细胞是无法发现的,甚至在 Crk 的 overexpression 之上,而缺乏仅仅是和 Fyn 的房间仍然与 phosphorylated Y307 包含了 Gab1。而且, Crk 导致了 Src-Y416 的 phosphorylation;因此,在 Crk 和 Csk 之间的相互作用被增加。Gab1-Y307F 异种没能近甚至在 HGF 之上本地化血浆膜刺激和减少的房间移植。而且, Gab1-Y307F 扰乱了 Crk, FAK,和 paxillin 的本地化,它是焦点的粘附的典型部件。一起拿,这些结果显示 Crk 通过 Src 便于 Gab1-Y307 的酷氨酸 phosphorylation,贡献焦点的粘附和提高的房间移植的组织,可能从而支持人的癌症开发。 | Takuya Watanabe Masumi Tsuda Yoshinori Makino Tassos Konstantinou Hiroshi Nishihara Tokifumi Majima Akio Minami Stephan M Feller Shinya Tanaka | 2009 | Cell Research2009，19，5： | 2 |
| 6 | Enhancement of cytotoxic T-lymphocyte responses in patients with gastrointestinal malignancies following vaccination with CEA peptide–pulsed dendritic cells显示文摘 | Kenji Matsuda Takuya Tsunoda Hajime Tanaka Yasukazu Umano Hiroshi Tanimura Ikuei Nukaya Kazutoh Takesako Hiroki Yamaue | 2004 | Cancer Immunology Immunotherapy2004，，7： | 1 |
| 7 | Results of immunotherapy for patients with unexplained secondary recurrent abortions显示文摘 | Hiroshi Adachi Koichi Takakuwa Takuya Mitsui Keisuke Ishii Masaki Tamura Kenichi Tanaka | 2003 | Clinical Immunology2003，，3： | 1 |
| 8 | Biliary reconstruction in pediatric live donor liver transplantation: duct-to-duct or Roux-en-Y hepaticojejunostomy显示文摘 | Hideaki Tanaka Akinari Fukuda Takanobu Shigeta Tatsuo Kuroda Takuya Kimura Seisuke Sakamoto Mureo Kasahara | 2010 | Journal of Pediatric Surgery2010，，8： | 1 |
| 9 | Hepatitis B Virus Reactivation in a Case of Non-Hodgkin’s Lymphoma Treated with Chemotherapy and Rituximab: Necessity of Prophylaxis for Hepatitis B Virus Reactivation in Rituximab Therapy显示文摘 | Yutaka Tsutsumi Takahito Kawamura Shin Saitoh Masahiro Yamada Shinji Obara Takuya Miura Hiroe Kanamori Junji Tanaka Masahiro Asaka Masahiro Imamura Nobuo Masauzi | 2004 | Leukemia & Lymphoma2004，，3： | 1 |
| 10 | Linkage of Familial Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis) to Chromosome 17q25显示文摘 | Tohru Yamauchi Mitsuhiro Tada Kiyohiro Houkin Toshihiro Tanaka Yusuke Nakamura Satoshi Kuroda Hiroshi Abe Takuya Inoue Kiyonobu Ikezaki Toshio Matsushima Masashi Fukui | 2000 | Stroke: Journal of the American Heart Association2000，，： | 1 |
| 11 | Severity of non‐alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle显示文摘 | Yoichiro Kitajima Hideyuki Hyogo Yoshio Sumida Yuichiro Eguchi Naofumi Ono Takuya Kuwashiro Kenichi Tanaka Hirokazu Takahashi Toshihiko Mizuta Iwata Ozaki Takahisa Eguchi Yuki Kimura Kazuma Fujimoto Keizo Anzai | 2013 | J Gastroenterol Hepatol2013，，9： | 1 |
| 12 | The Relationship Between the Anatomy of the Nuchal Ligament and Postoperative Axial Pain After Cervical Laminoplasty: Cadaver and Clinical Study显示文摘 | Atsushi Ono Yoshikazu Tonosaki Takuya Numasawa Kanichiro Wada Yoshihito Yamasaki Toshihiro Tanaka Gentaro Kumagai Shuichi Aburakawa Kazunari Takeuchi Toru Yokoyama Kazumasa Ueyama Yasuyuki Ishibashi Satoshi Toh | 2012 | Spine2012，，26： | 1 |
| 13 | Conductance Measurement of a DNA Network in Nanoscale by Point Contact Current Imaging Atomic Force Microscopy显示文摘 | Ayumu Terawaki Yoiehi Otsuka HeaYeon Lee Takuya Matsumoto Hidekazu Tanaka Tomoji Kawai | 2005 | Appl Phys Lett2005，86，11： | 1 |
| 14 | Mechanical properties of cross-linked polymer particles prepared by nitroxide- mediated radical polymerization in aqueous micro-suspension 显示文摘 | Takuya Tanaka Toyoko Suzuki Yuichi Saka Per B Zetterlund Masayoshi Okubo | 2007 | Polymer2007，48，： | 1 |
| 15 | Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection显示文摘 | Toshihiko Tomita Yongmin Kim Takahisa Yamasaki Takuya Okugawa Takashi Kondo Fumihiko Toyoshima Jun Sakurai Junji Tanaka Tsuyoshi Morita Tadayuki Oshima Hirokazu Fukui Kazutoshi Hori Jiro Watari Takayuki Matsumoto Hiroto Miwa | 2012 | Journal of Gastroenterology and Hepatology2012，，9： | 1 |
| 16 | Capturing of bisphenol A photodecomposition intermediates by composite TiO2-zeolite sheets显示文摘 | Shuji Fukahori Hideaki Ichiura Takuya Kitaoka Hiroo Tanaka | 2003 | Applied Catalysis B: Environmental2003，，46： | 1 |
| 17 | A new catechin oxidation product and polymeric polyphenols of post-fermented tea显示文摘 | He-yuan Jiang Takuya Shii Yosuke Matsuo Takashi Tanaka Zhi-Hong Jiang Isao Kouno | 2011 | Food Chemistry2011，，3： | 1 |
| 18 | Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese显示文摘 | Akira Shimada Yasuhiko Kanazawa Yoshiko Motohashi Satoru Yamada Taro Maruyama Hiroshi Ikegami Takuya Awata Eiji Kawasaki Tetsuro Kobayashi Koji Nakanishi Yumiko Kawabata Susumu Kurihara Miho Uga Shoichiro Tanaka | 2007 | Journal of Autoimmunity2007，，4： | 1 |
| 19 | Genetic Differences in the Osteogenic Differentiation Potency According to the Classification of Ossification of the Posterior Longitudinal Ligament of the Cervical Spine显示文摘 | Hitoshi Kudo Ken-Ichi Furukawa Toru Yokoyama Atsushi Ono Takuya Numasawa Kanichiro Wada Sunao Tanaka Toru Asari Kazumasa Ueyama Shigeru Motomura Satoshi Toh | 2011 | Spine2011，，12： | 1 |
| 20 | Studies on the prevalence of human papillomavirus in pregnant women in Japan显示文摘 | Koichi Takakuwa Takuya Mitsui Mitsutoshi Iwashita Iwao Kobayashi Akira Suzuki Takaaki Oda Yuichi Torii Masahiko Matsumoto Goki Yahata Kenichi Tanaka | 2006 | Journal of Perinatal Medicine2006，，1： | 1 |
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