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| 1 | Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize显示文摘 | Haijun Liu Xin Luo Luyao Niu Yingjie Xiao Lu Chen Jie Liu Xiaqing Wang Minliang Jin Wenqiang Li Qinghua Zhang Jianbing Yan | 2017 | Molecular Plant2017，10，3： | 13 |
| 2 | Genome-wide analysis of BES1 genes in Gossypium revealed their evolutionary conserved roles in brassinosteroid signaling显示文摘Brassinosteroids(BRs), which are essential phytohormones for plant growth and development, are important for cotton fiber development. Additionally, BES1 transcription factors are critical for BR signal transduction. However, cotton BES1 family genes have not been comprehensively characterized. In this study, we identified 11 BES1 genes in G. arboreum, 11 in G.raimondii, 16 in G. barbadense, and 22 in G. hirsutum. The BES1 sequences were significantly conserved in the Arabidopsis thaliana, rice, and upland cotton genomes. A total of 94 BES1 genes from 10 different plant species were divided into three clades according to the neighbor-joining and minimum-evolution methods. Moreover, the exon/intron patterns and motif distributions were highly conserved among the A. thaliana and cotton BES1 genes. The collinearity among the orthologs from the At and Dt subgenomes was estimated. Segmental duplications in the At and Dt subgenomes were primarily responsible for the expansion of the cotton BES1 gene family. Of the GhBES1 genes, GhBES1.4_At/Dt exhibited BL-induced expression and was predominantly expressed in fibers. Furthermore, Col-0/mGhBES1.4_At plants produced curled leaves with long and bent petioles. These transgenic plants also exhibited decreased hypocotyl sensitivity to brassinazole and constitutive BR induced/repressed gene expression patterns. The constitutive BR responses of the plants overexpressing mGhBES1.4_At were similar to those of the bes1-D mutant. | Zhao Liu Ghulam Qanmber Lili Lu Wenqiang Qin Ji Liu Jie Li Shuya Ma Zhaoen Yang Zuoren Yang | 2018 | Science China(Life Sciences)2018，61，12： | 7 |
| 3 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 4 | Hepatocellular carcinoma and intrahepatic cholangiocarcinoma incidence between 2006 and 2015 in China: estimates based on data from 188 population-based cancer registries显示文摘Background:Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)are the most common subtypes of primary liver cancer,but nationwide incidence of both liver cancer subtypes have never been reported in China.We aimed to estimate the most recent incidence of HCC and ICC and temporal trends in China based on the most updated data from high qualified population-based cancer registries(covering 13.1%of the national population),in comparison to those in the United States at the same period.Methods:We used data from 188 Chinese population-based cancer registries covering 180.6 million population of China to estimate the nationwide incidence of HCC and ICC in 2015.And 22 population-based cancer registries’data were used to estimate the trends of HCC and ICC incidence from 2006 to 2015.Multiple imputation by chained equations method was used to impute liver cancer cases with unknown subtype(50.8%).We used data from 18 population-based registries from the Surveillance,Epidemiology,and End Results program to analyze incidence of HCC and ICC in the United States.Results:In China,an estimated 301,500 and 61,900 newly diagnosed HCC and ICC occurred in 2015.The overall age-standardized rates(ASRs)of HCC incidence decreased by 3.9%per year.For ICC incidence,the overall ASR was relatively stable,but increased in the population of over 65 years old.Subgroup analysis by age showed that the ASR of HCC incidence had the sharpest decline in population who were less than 14 years old and received neonatally hepatitis B virus(HBV)vaccination.In the United States,though the incidence of HCC and ICC were lower than those in China,the overall HCC and ICC incidence increased by 3.3%and 9.2%per year.Conclusions:China still faces with a heavy burden of liver cancer incidence.Our results may further support the beneficial effect of Hepatitis B vaccination on reduction of HCC incidence.Both healthy lifestyle promotion and infection control are needed for future liver cancer control and prevention for China and the United States. | Lan An Rongshou Zheng Siwei Zhang Ru Chen Shaoming Wang Kexin Sun Lingeng Lu Xuehong Zhang Hong Zhao Hongmei Zeng Wenqiang Wei Jie He | 2023 | Hepatobiliary Surgery and Nutrition2023，12，1： | 4 |
| 5 | Study on Laminar Natural Convection Heat Transfer from a Hemisphere with Uniform Heat Flux Surface显示文摘By employing the modified model based on Bejan et al., laminar natural convection heat transfer from a hemisphere with uniform heat flux surface has been numerically investigated. Extensive results of two different surface boundary conditions are obtained for a wide range of Grashof numbers(10 ≤ Gr ≤ 10~7) and Prandlt number of 0.72. The characteristics of heat transfer and fluid flow are analyzed in terms of isotherm contours and streamline patterns, radial and tangential velocities, dimensionless temperature profiles, local friction and pressure drag coefficients, as well as local and average Nusselt numbers. Meanwhile, the effects of Grashof number and adiabatic surface on flow motion and heat transfer have been studied. No recirculation zone or flow separation generates over the top of the hemisphere compared to the isothermal sphere. Owing to the curvature effect, the maximum values of local friction and pressure drag coefficients appear at the corner point B. Comparisons with the previous results are also reported in detail. All the results are in good agreement with the numerical data. Moreover, both local and average Nusselt numbers show a positive dependence on Grashof number. The values of the non-adiabatic case are smaller than that of the adiabatic case due to the preheating effect. Finally, two precise and general correlations of average Nusselt number varying with Grashof numbers have been presented, which can provide an effective prediction for the heat transfer rate in engineering applications, and offer academic values for the future research. | ZHANG Jian LIU Jie LU Wenqiang | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 6 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 7 | Preliminary study of non-isothermal phase change phenomena in vertical Bridgman crystal growth显示文摘Axisymmetric dual reciprocity boundary element method (DRBEM) with augmented items is extended to simulate the heat and mass transfer problems in the vertical Bridgman method (VBM) crystal growth of HgCdTe and CdZnTe. Axial solute concentration redistribution of three regions numerically reap-pears, and the influence of the pulling rate of the ampoule on it is further studied. Secondly, one di-mensional transient phase change phenomena is studied, and non-isothermal phase change phe-nomena is obtained from the initial transient region through the steady growth region to the final tran-sient region. Thirdly, the two-dimensional axisymmetric phase change interface position, interfacial shape and the temperature field of the melt and the crystal are numerically captured under the condi-tion to arrive at the steady state with zero pulling rate of the ampoule. Finally, the study of transient axisymmetric non-isothermal phase change phenomena is stressed and the results are compared with those in isothermal phase change. The influence of the pulling rate on non-isothermal phase change phenomena is revealed. | LIU Jie LU WenQiang | 2007 | Chinese Science Bulletin2007，52，5： | 2 |
| 8 | Steganography Using Reversible Texture Synthesis Based on Seeded Region Growing and LSB显示文摘Steganography technology has been widely used in data transmission with secret information.However,the existing steganography has the disadvantages of low hidden information capacity,poor visual effect of cover images,and is hard to guarantee security.To solve these problems,steganography using reversible texture synthesis based on seeded region growing and LSB is proposed.Secret information is embedded in the process of synthesizing texture image from the existing natural texture.Firstly,we refine the visual effect.Abnormality of synthetic texture cannot be fully prevented if no approach of controlling visual effect is applied in the process of generating synthetic texture.We use seeded region growing algorithm to ensure texture’s similar local appearance.Secondly,the size and capacity of image can be decreased by introducing the information segmentation,because the capacity of the secret information is proportional to the size of the synthetic texture.Thirdly,enhanced security is also a contribution in this research,because our method does not need to transmit parameters for secret information extraction.LSB is used to embed these parameters in the synthetic texture. | Qili Zhou Yongbin Qiu Li Li Jianfeng Lu Wenqiang Yuan Xiaoqing Feng Xiaoyang Mao | 2018 | Computers, Materials & Continua2018，，4： | 2 |
| 9 | Cobalt phosphide nanoparticles supported within network of N-doped carbon nanotubes as a multifunctional and scalable electrocatalyst for water splitting显示文摘In order to realize industrial production of hydrogen through water splitting,it is essential to develop a cost-efficient and scalable approach to synthesize nonprecious electrocatalysts with sufficiently high activity and stability to replace commercial noble-metal-based electrocatalysts.Herein we synthesize cobalt phosphide nanoparticles dispersed within nitrogen-doped carbon nanotube network(CP@NCNT) via scalable spray drying and thermal treatments.As a multifunctional electrocatalyst,the CP@NCNT hybrid delivers outstanding activity for HER(in both acidic and alkaline electrolytes),OER and overall water splitting.Remarkably,it shows an ultra-low overpotental of 94 mV to obtain 10 mA cm-2 in HER.It also demonstrates outstanding activity in overall water splitting,requiring only 1.619 V to deliver 10 mA cm-2with more than 72 h’ long-term stability.The combination of notable performance,multi-functionality and highly scalable spray-drying synthesis method enables this material as a novel and cost-efficient transition metal-based electrocatalysts for overall water splitting. | Dongxu Yang Wenqiang Hou Yingjiong Lu Wanli Zhang Yuanfu Chen | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 10 | effect on some thermophysical Study for the particle's scale properties of nanofluids by a simplified molecular dynamics method 显示文摘 | LU Wenqiang FAN Qingmei | 2008 | Engineering Analysis with Boundary Elements2008，32，： | 1 |
| 11 | Anomalous Enhancement in Thermal Conductivity ofNanofluid Induced by Solid Walls in a Nanochannel显示文摘 | SUN Chengzhen LU Wenqiang BAI Bofeng | 2011 | Applied Thermal Engineering2011，31，17： | 1 |
| 12 | Study for the Parti-cle,S Scale Effect on Some Thermophysical Properties ofNanofluids by a Simplified Molecular Dynamics Method显示文摘 | LU Wenqiang FAN Qingmei | 2008 | Engineering Analysis with Boundary Element2008，32，4： | 1 |
| 13 | Molec- ular Dynamics Simulation of Nanofluid's Effective Ther- mal Conductivity in High-Shear-Rate Couette Flow 显示文摘 | SUN Chengzhen LU Wenqiang BAI Bofeng | 2011 | International Journal of Heat and Mass Transfer2011，54，11： | 1 |
| 14 | Sustainable silicon anodes facilitated via a double-layer interface engineering: Inner SiOx combined with outer nitrogen and boron co-doped carbon显示文摘Silicon-based(Si)materials are promising anodes for lithium-ion batteries(LIBs)because of their ultrahigh theoretical capacity of 4200 mA h g^(−1).However,commercial applications of Si anodes have been hindered by their drastic volume variation(∼300%)and low electrical conductivity.Here,to tackle the drawbacks,a hierarchical Si anode with double-layer coatings of a SiOx inner layer and a nitrogen(N),boron(B)co-doped carbon(C-NB)outer layer is elaborately designed by copyrolysis of Si-OH structures and a H3BO_(3)-doped polyaniline polymer on the Si surface.Compared with the pristine Si anodes(7mA h g^(−1) at 0.5 A g^(−1) after 340 cycles and 340 mA h g^(−1) at 5 A g^(−1)),the modified Si-based materials(Si@SiOx@C-NB nanospheres)present su perior cycling stability(reversible 1301 mA h g^(−1) at 0.5 A g^(−1) after 340 cycles)as well as excellent rate capability(690mA h g^(−1) at 5 A g^(−1))when used as anodes in LIBs.The unique double-layer coating structure,in which the inner amorphous SiOx layer acts as a buffer matrix and the outer defect-rich carbon enhances the electron diffusion of the whole anode,makes it possible to de liver excellent electrochemical properties.These results indicate that our double-layer coating strategy is a promising approach not only for the devel opment of sustainable Si anodes but also for the design of multielement-doped carbon nanomaterials. | Jun Zhou Yao Lu Lishan Yang Wenqiang Zhu Weifang Liu Yahui Yang Kaiyu Liu | 2022 | Carbon Energy2022，4，3： | 1 |
| 15 | Molecu-lar Dynamics Simulation of Nanofluid's Effective ThermalConductivity in High-Shear-Rate Couette Flow显示文摘 | SUN Chengzhen LU Wenqiang LIU Jie | 2011 | Inter-national Journal of Heat and Mass Transfer2011，54，11： | 1 |
| 16 | Shear-Rate Dependent Effective Thermal Conductivity of H2O+SiO2 Nanofluids显示文摘 | SUN Chengzhen LU Wenqiang BAI Bofeng | 2013 | Physics of Fluids2013，25，05： | 1 |
| 17 | A computational design of a magnetic field applied to control magnetic adsorbent used in liquid/gas adsorption processes显示文摘 | Lu Junfeng Zhang Hao Lu Wenqiang | 2014 | International Communications in Heat and Mass Transfer2014，53，3： | 1 |
| 18 | Enhanced production of Co Q10 by constitutive overexpression of 3- demethyl ubiquinone-9 3-methyhransferase under tac promoter in Rhodobacter sphaeroides显示文摘 | Lu Wenqiang Shi Yijun He Shuaiwei | 2013 | Biochemical Engineer- ing Journal2013，72，： | 1 |
| 19 | Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation/Hydroxymethylation in Reprogramming显示文摘 | Yawei Gao Jiayu Chen Ke Li Tong Wu Bo Huang Wenqiang Liu Xiaochen Kou Yu Zhang Hua Huang Yonghua Jiang Chao Yao Xiaolei Liu Zhiwei Lu Zijian Xu Lan Kang Jun Chen Hailin Wang Tao Cai Shaorong Gao | 2013 | Cell Stem Cell2013，，： | 1 |
| 20 | Transcriptome and weighted gene co-expression network analysis of jujube(Ziziphus jujuba Mill.)fruit reveal putative genes involved in proanthocyanin biosynthesis and regulation显示文摘Proanthocyanidin(PA)is an important bioactive compound with multiple physiological benefits in jujube(Ziziphus jujube Mill.).However,the molecular mechanisms underlying PA biosynthesis in jujube fruit have not been investigated.Here,the profiling of PA,(+)-catechin and(–)-epicatechin and transcriptome sequencing of three jujube cultivars from Xinjiang Uyghur Autonomous Region of China at five developmental stages were analyzed.The levels of total PAs and catechin exhibited a decreased trend over jujube ripening,and epicatechin content of two jujube cultivars increased first and then declined.Transcriptome analysis revealed that the differentially expressed genes(DEGs)were mainly enriched in ribosome,glycolysis/gluconeogenesis,fructose and mannose metabolism.17 DEGs encoding PAL,CHS,CHI,CHS,F3'H,LAR,ANR,C4Hs,4CLs,FLSs,DFRs and UFGTs involved in PA biosynthesis were relatively abundant.The highly transcribed LAR gene may greatly contribute to epicatechin accumulation.A weighted gene co-expression network analysis(WGCNA)was performed,and a network module including 1620 genes highly correlated with content of Pas and catechin was established.We identified 58 genes including 9 structural genes and 49 regulatory genes related to PA biosynthesis and regulation in the WGCNA module.Sixteen genes encoding 9 families of transcriptional factors(i.e.,MYB,bHLH,ERF,bZIP,NAC,SBP,MIKC,HB,WRKY)were considered as hub genes.The results of qRT-PCR analysis validating 10 genes were well consistent with the transcriptome data.These findings provide valuable knowledge to facilitate its genetic studies and molecular breeding. | Wenqiang Wang Yunfeng Pu Hao Wen Dengyang Lu Min Yan Minzhe Liu Minyu Wu Hongjin Bai Lirong Shen Cuiyun Wu | 2023 | Food Science and Human Wellness2023，12，5： | 1 |
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