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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 3 | Contrasting trends of PM2.5 and surface-ozone concentrations in China from 2013 to 2017显示文摘Although much attention has been paid to investigating and controlling air pollution in China,the trends of air-pollutant concentrations on a national scale have remained unclear.Here,we quantitatively investigated the variation of air pollutants in China using long-term comprehensive data sets from 2013 to 2017,during which Chinese government made major efforts to reduce anthropogenic emission in polluted regions.Our results show a significant decreasing trend in the PM2.5 concentration in heavily polluted regions of eastern China,with an annual decrease of〜7%compared with measurements in 2013.The measured decreased concentrations of SO2>NO2 and CO(a proxy for anthropogenic volatile organic compounds)could explain a large fraction of the decreased PM2.5 concentrations in different regions.As a consequence;the heavily polluted days decreased significantly in corresponding regions.Concentrations of organic aerosol;nitrate;sulfate,ammonium and chloride measured in urban Beijing revealed a remarkable reduction from 2013 to 2017;connecting the decreases in aerosol precursors with corresponding chemical components closely.However;surface-ozone concentrations showed increasing trends in most urban stations from 2013 to 2017;which indicates stronger photochemical pollution.The boundary-layer height in capital c让ies of eastern China showed no significant trends over the Beijing-Tianjin-Hebei,Yangtze River Delta and Pearl River Delta regions from 2013 to 2017;which confirmed the reduction in anthropogenic emissions.Our results demonstrated that the Chinese government was successful in the reduction of particulate matter in urban areas from 2013 to 2017,although the ozone concentration has increased significantly;suggesting a more complex mechanism of improving Chinese air quality in the future. | Yonghong Wang Wenkang Gao Shuai Wang Tao Song Zhengyu Gong Dongsheng Ji Lili Wang Zirui Liu Guiqian Tang Yanfeng Huo Shili Tian Jiayun Li Mingge Li Yuan Yang Biwu Chu Tuukka Petaja Veli-Matti Kerminen Hong He Jiming Hao Markku Kulmala Yuesi Wang Yuanhang Zhang | 2020 | National Science Review2020，7，8： | 51 |
| 4 | Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis显示文摘Baicalein, wogonin,和他们的 glycosides 是在药用的植物黄芩 baicalensis Georgi 发现的主要 bioactive 混合物。这些黄酮能在许多癌症房间线导致 apoptosis,但是没在正常房间上有效果。而且,他们为人的健康有许多另外的好处,例如抗氧化剂,抗病毒、肝保护的性质。这里,我们报导二 CYP450 酶, SbCYP82D1.1 和 SbCYP82D2 的隔离和描述,分别地,它在 S. 作为黄酮 6-hydroxylase (F6H ) 和黄酮 8-hydroxylase (F8H ) 工作 ? baicalensis。SbCYP82D1.1 为象 chrysin 和 apigenin 那样的黄酮有宽广底层特性并且在根和 S. 的天线部分为 baicalein 和 scutellarein 的生合成负责 ? baicalensis 分别地。当 SbCYP82D1.1 的表示被击倒时,当时, baicalin 和 baicalein 层次显著地被减少 chrysin glycosides 在毛乎乎的根积累。SbCYP82D2 是有高底层特性的 F8H,接受仅仅象它生产 norwogonin 的底层的 chrysin,尽管次要的 6-hydroxylation 活动能也被检测。种系发生的分析建议 SbCYP82D2 可能经由 neofunctionalization 跟随的基因复制从 SbCYP82D1.1 演变,祖先的 F6H 活动由此部分在导出的 SbCYP82D2 被保留。 | Qing Zhao Meng-Ying Cui Olesya Levsh Dongfeng Yang Jie Liu Jie Li Lionel Hill Lei Yang Yonghong Hu Jing-Ke Weng Xiao-Ya Chen Cathie Martin | 2018 | Molecular Plant2018，11，1： | 30 |
| 5 | Three-dimensional crustal velocity structure model of the middle-eastern north China Craton (HBCrust1.0)显示文摘Lithosphere thinning and destruction in the middle-eastern North China Craton(NCC), a region susceptible to strong earthquakes, is one of the research hotspots in solid earth science. All 42 seismic wide-angle reflection/refraction profiles have been completed in the middle-eastern NCC. We collect all the 2-D profiling results and perform gridding of the velocity and interface depth data, building a 3-D crustal velocity structure model for the middle-eastern NCC, named HBCrust1.0, by using the Kriging interpolation method. Our result shows that the first-arrival times calculated by HBCust1.0 fit well with the observations. The result demonstrates that the upper crust is the main seismogenic layer, and the brittle-ductile transition occurs at depths near interface C(the interface between upper and lower crust). The depth of interface Moho varies beneath the source area of the Tangshan earthquake, and a low-velocity structure is found to extend from the source area to the lower crust. Based on these observations, it can be inferred that stress accumulation responsible for the Tangshan earthquake may have been closely related to the migration and deformation of the mantle materials. Comparisons of the average velocities of the whole crust, the upper and the lower crust show that the average velocity of the lower crust under the central part of the North China Basin(NCB) in the east of the craton is obviously higher than the regional average. This high-velocity probably results from long-term underplating of the mantle magma. | DUAN YongHong WANG FuYun ZHANG XianKang LIN JiYan LIU Zhi LIU BaoFeng YANG ZhuoXin GUO WenBin WEI YunHao | 2016 | Science China Earth Sciences2016，59，7： | 24 |
| 6 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 7 | Review of Electronic Speckle Pattern Interferometry(ESPI) for Three Dimensional Displacement Measurement显示文摘Three dimensional(3D)displacements,which can be translated further into 3D strain,are key parameters for design,manufacturing and quality control.Using different optical setups,phase-shift methods,and algorithms,several different 3D electronic speckle pattern interferometry(ESPI)systems for displacement and strain measurements have been achieved and commercialized.This paper provides a review of the recent developments in ESPI systems for 3D displacement and strain measurement.After an overview of the fundamentals of ESPI theory,temporal phase-shift,and spatial phase-shift techniques,3D deformation measurements by the temporal phase-shift ESPI system,which is suited well for static measurement,and by the spatial phase-shift ESPI system,which is particularly useful for dynamic measurement,are discussed.For each method,the basic theory,a brief derivation and different optical layouts are presented.The state of art application,potential and limitation of the ESPI systems are shown and demonstrated. | YANG Lianxiang XIE Xin ZHU Lianqing WU Sijin WANG Yonghong | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 20 |
| 8 | Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species显示文摘 | Jian Wu Yuefeng Sun Yannan Zhao Jian Zhang Lilan Luo Meng Li Jinlong Wang Hong Yu Guifu Liu Liusha Yang Guosheng Xiong Jian-Min Zhou Jianru Zuo Yonghong Wang Jiayang Li | 2015 | Cell Research2015，25，5： | 13 |
| 9 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 10 | Precise measurement of stable (δ^(88/86)Sr) and radiogenic (^(87)Sr/^(86)Sr) strontium isotope ratios in geological standard reference materials using MC-ICP-MS显示文摘A new method for high-precision measurements of stable (δ88/86Sr) and radiogenic (87Sr/86Sr) Sr isotope ratios was developed on the MC-ICP-MS using a standard-sample-standard bracketing protocol. By carefully monitoring and controlling the accumulation of the on-peak backgrounds (i.e. the carryover memory) on the instrument, our method can provide an external precision of around 0.010‰ to 0.014‰ for 88/86 Sr measurements. Such precision is comparable to that achieved by double-spike TIMS method (DS-TIMS), and 2-3 times better than those of the previously reported results by MC-ICP-MS without spiking. The results of the standard seawater IAPSO are also identical to those by DS-TIMS. However, our method is more advantageous, efficient and convenient to use for routine Sr isotopic analysis than the DS-TIMS method as there is no need to prepare and calibrate the 84Sr-87 Sr double spike. Using this method, we measured the δ88/86Sr values in a series of international geological rock standards, which show large variability, with the lowest value (0.20‰) registered in JG-2, a terrestrial granite, and the highest value (0.539‰) in UB-N, a serpentinite. This may provide an additional means for isotopic characterization of geological processes, adding a new dimension over the traditional use of radiogenic Sr isotopic ratio 87Sr/86Sr. | MA JinLong WEI GangJian LIU Ying REN ZhongYuan XU YiGang YANG YongHong | 2013 | Chinese Science Bulletin2013，58，25： | 9 |
| 11 | A Study of Tensile Strength Tests of Arborous Species Root System in Forest Engineering Technique of Shallow Landslide显示文摘One experiment was conducted, through tensile tests of Albazzia and Eucalypt roots culled from the fields. The other experiment was conducted, by testing anti-drawing strength of these root systems in the Albazzia and Eucalypt lands. These two experiments had an aim to give insights into the maximum tensile strength and anti-drawing strength of the root systems. Results indicated that the maximum tensile strength of root system is in an exponential relation with the diameter of root system while the maximum tensile strength is positively correlative with the diameter of root system. Anti-drawing force of root system together with root diameter, length, and soil bulk density are folded into a regression equation in an attempt to figure out the static friction coefficient between root system and its ambient soil. | YANG Yonghong LIU Shuzhen WANG Chenghua TANG Chuan | 2006 | Wuhan University Journal of Natural Sciences2006，11，4： | 6 |
| 12 | Effect of wastewater composition on the calcium carbonate precipitation in upflow anaerobic sludge blanket reactors显示文摘Calcium carbonate often precipitates in anaerobic reactors treating wastewater with high calcium content.The aim of this paper is to study the effect of wastewater composition on calcium carbonate precipitation in upflow anaerobic sludge blanket(UASB)reactors.Two laboratory-scale UASB reactors were operated with calcium-containing influents using acetate and carbohydrate as substrate,respectively.There was an obvious accumulation of inorganic precipitate observed in the biogranules.Observations via scanning electron microscope(SEM)and energy dispersive spectroscopy(EDS)showed that the acclimated biogranules in the two reactors differed in microstructure.Calcium carbonate was found to have precipitated on the surface of acetate-degrading biogranules,but precipitated at the core of the carbohydrate-degrading biogranules.The results indicated that substrates had significant influence on the location of calcium carbonate precipitation in anaerobic granular sludge,which was expected due to the different methanogens distribution and pH gradient within the granular sludge degrading various substrates.Moreover,the location of calcium carbonate precipitation substantially affected the specific methanogenic activity(SMA)of the granular sludge.The SMA of the acetate-degrading biogranules dropped from 1.96 gCODCH4·gVSS^(–1)·d^(–1)to 0.61 gCODCH4·gVSS^(–1)·d^(–1)after 180-d of operation in the reactor.However,the SMA of the carbohydrate-degrading biogranules was not adversely affected by calcium carbonate precipitation. | Shucheng YANG Yanling HE Yonghong LIU Charles CHOU Pengxiang ZHANG Dongqi WANG | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 6 |
| 13 | Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z.bungeanum genome显示文摘Zanthoxylum bungeanum is an important spice and medicinal plant that is unique for its accumulation of abundant secondary metabolites,which create a characteristic aroma and tingling sensation in the mouth.Owing to the high proportion of repetitive sequences,high heterozygosity,and increased chromosome number of Z.bungeanum,the assembly of its chromosomal pseudomolecules is extremely challenging.Here,we present a genome sequence for Z.bungeanum,with a dramatically expanded size of 4.23 Gb,assembled into 68 chromosomes.This genome is approximately tenfold larger than that of its close relative Citrus sinensis.After the divergence of Zanthoxylum and Citrus,the lineage-specific whole-genome duplication event q-WGD approximately 26.8 million years ago(MYA)and the recent transposable element(TE)burst~6.41 MYA account for the substantial genome expansion in Z.bungeanum.The independent Zanthoxylum-specific WGD event was followed by numerous fusion/fission events that shaped the genomic architecture.Integrative genomic and transcriptomic analyses suggested that prominent speciesspecific gene family expansions and changes in gene expression have shaped the biosynthesis of sanshools,terpenoids,and anthocyanins,which contribute to the special flavor and appearance of Z.bungeanum.In summary,the reference genome provides a valuable model for studying the impact of WGDs with recent TE activity on gene gain and loss and genome reconstruction and provides resources to accelerate Zanthoxylum improvement. | Shijing Feng Zhenshan Liu Jian Cheng Zihe Li Lu Tian Min Liu Tuxi Yang Yulin Liu Yonghong Liu He Dai Zujun Yang Qing Zhang Gang Wang Jisen Zhang Huifeng Jiang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 5 |
| 14 | MoS2 nanorods with inner caves through synchronous encapsulation of sulfur for high performance Li–S cathodes显示文摘Lithium–sulfur(Li–S)batteries have become one of the most promising candidates for next-generation batteries owing to their high specific capacity,low cost,and environment-friendliness.Many efforts have been made to mitigate the'shuttle effect'through physical adsorption and chemical bonding.MoS2 has been proposed as a cathode material to provide effective anchoring sites for lithium polysulfides(Li PSs),but is still limited by its layer structure.Herein,we designed novel MoS2 nanorods with inner caves based on our previous work,and performed synchronous encapsulation of sulfur during the synthesis process.The outer MoS2 tubular shells physically inhibit the outward diffusion of polysulfide species while the inner particles chemically anchor the polysulfides to prevent shuttling.As the cathode matrix in Li–S batteries,the electrochemical results deliver a high initial discharge capacity of 1213 mAhg^-1 for sulfur at 0.1 C.After cycling at 1 C for 300 cycles,the cells exhibit a capacity decay of only 0.076%per cycle and high average coulombic efficiency over 95%.The tubular MoS2 structure is an innovative and appealing design,which could be regarded as a prospective substrate for the improved performance of Li–S batteries. | Yikun Yi Zechen Liu Pu Yang Tao Wang Xuewen Zhao Hongyang Huang Yonghong Cheng Jinying Zhang Mingtao Li | 2020 | Journal of Energy Chemistry2020，29，6： | 5 |
| 15 | Multi-perspective digital image correlation method using a single color camera显示文摘A novel 3 D digital image correlation(DIC) system based on a single three charge-couple device(3 CCD) color camera is proposed in this paper. Images from three different perspectives are captured by a 3 CCD camera using a reflective-based pseudo-vision system. These images are then separated by the different CCD channels, and the correlation algorithm for the multi-camera DIC system is adopted to evaluate the images. Compared to the conventional multi-camera DIC system, the proposed system is much more compact. In addition, the proposed system has no loss of spatial resolution, compares to the traditional single camera DIC system. The complex surface measurement ability and the measurement accuracy is significantly improved through the use of the multi-camera DIC algorithm. The principle of the proposed system is described in detail as well as the experimental setup. A series of validation tests are performed, and the results are verified with the commercial 3 D-DIC system. | WANG YongHong DAN XiZuo LI JunRui WU SiJin YANG LianXiang | 2018 | Science China(Technological Sciences)2018，61，1： | 5 |
| 16 | Engineering optimization approach of nonaqueous electrolyte for sodium ion battery with long cycle life and safety显示文摘Electrolyte design strategies are closely related to the capacities, cycle life and safety of sodium–ion batteries. In this study, we aimed to optimize electrolyte with the focus on engineering aspects. The basic physicochemical properties including ionic conductivity, viscosity,wettability and thermochemical stability of the electrolytes using Na PF6 as the solute and the mixed solvent with different components of EMC,DMC or DEC in PC or EC were systematically measured. Ah pouch cell with NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon electrodes was used to evaluate the performance of the prepared electrolytes. By using the Inductive Coupled Plasma Emission Spectrometer(ICP), X-ray photoelectron spectroscopy(XPS), Thermogravimetric-differential scanning calorimetry(TG-DSC) and Accelerating Rate Calorimeter(ARC), we show that an optimized electrolyte can effectively promote the formation of a protective interfacial layer on two electrodes, which not only retards parasitic reactions between the electrodes and electrolyte but also suppresses dissolution of metal ions from the cathode. With an optimized electrolyte, a NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)/hard carbon cell can attain 56.16% capacity retention under the low temperature of -40℃, and can be able to retain 80%capacity retention after more than 2500 cycles while presenting excellent thermal safety. | Haiying Che Xinrong Yang Yan Yu Chaoliang Pan Hong Wang Yonghong Deng Linsen Li Zi-Feng Ma | 2021 | Green Energy & Environment2021，6，2： | 4 |
| 17 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 18 | Fabrication of 4H-SiC n-channel IGBTs with ultra high blocking voltage显示文摘Owing to the conductivity modulation of silicon carbide(Si C) bipolar devices, n-channel insulated gate bipolar transistors(n-IGBTs) have a significant advantage over metal oxide semiconductor field effect transistors(MOSFETs) in ultra high voltage(UHV) applications. In this paper, backside grinding and laser annealing process were carried out to fabricate 4 H-Si C n-IGBTs. The thickness of a drift layer was 120 μm, which was designed for a blocking voltage of 13 k V. The n-IGBTs carried a collector current density of 24 A/cm^2 at a power dissipation of300 W/cm^2 when the gate voltage was 20 V, with a differential specific on-resistance of 140 mΩ·cm^2. | Xiaolei Yang Yonghong Tao Tongtong Yang Runhua Huang Bai Song | 2018 | Journal of Semiconductors2018，39，3： | 4 |
| 19 | Ferrimagnetic m PEG-b-PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermia–chemotherapy显示文摘As a non-invasive therapeutic method without penetration-depth limitation,magnetic hyperthermia therapy(MHT)under alternating magnetic field(AMF)is a clinically promising thermal therapy.However,the poor heating conversion efficiency and lack of stimulus–response obstruct the clinical application of magnetofluid-mediated MHT.Here,we develop a ferrimagnetic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)(m PEG-b-PHEP)copolymer micelle loaded with hydrophobic iron oxide nanocubes and emodin(denoted as EMM).Besides an enhanced magnetic resonance(MR)contrast ability(r2=271 m M^-1 s^-1)due to the high magnetization,the specific absorption rate(2518 W/g at 35 k A/m)and intrinsic loss power(6.5 n Hm2/kg)of EMM are dozens of times higher than the clinically available iron oxide nanoagents(Feridex and Resovist),indicating the high heating conversion efficiency.Furthermore,this composite micelle with a flowable core exhibits a rapid response to magnetic hyperthermia,leading to an AMF-activated supersensitive drug release.With the high magnetic response,thermal sensitivity and magnetic targeting,this supersensitive ferrimagnetic nanocomposite realizes an above 70%tumor cell killing effect at an extremely low dosage(10μg Fe/m L),and the tumors on mice are completely eliminated after the combined MHT–chemotherapy. | Yonghong Song Dongdong Li Yang Lu Kun Jiang Yi Yang Yunjun Xu Liang Dong Xu Yan Daishun Ling Xianzhu Yang Shu-Hong Yu | 2020 | National Science Review2020，7，4： | 4 |
| 20 | Traditional Chinese Medicine Automated Diagnosis Based on Knowledge Graph Reasoning显示文摘Syndrome differentiation is the core diagnosis method of Traditional Chinese Medicine(TCM).We propose a method that simulates syndrome differentiation through deductive reasoning on a knowledge graph to achieve automated diagnosis in TCM.We analyze the reasoning path patterns from symptom to syndromes on the knowledge graph.There are two kinds of path patterns in the knowledge graph:one-hop and two-hop.The one-hop path pattern maps the symptom to syndromes immediately.The two-hop path pattern maps the symptom to syndromes through the nature of disease,etiology,and pathomechanism to support the diagnostic reasoning.Considering the different support strengths for the knowledge paths in reasoning,we design a dynamic weight mechanism.We utilize Naïve Bayes and TF-IDF to implement the reasoning method and the weighted score calculation.The proposed method reasons the syndrome results by calculating the possibility according to the weighted score of the path in the knowledge graph based on the reasoning path patterns.We evaluate the method with clinical records and clinical practice in hospitals.The preliminary results suggest that the method achieves high performance and can help TCM doctors make better diagnosis decisions in practice.Meanwhile,the method is robust and explainable under the guide of the knowledge graph.It could help TCM physicians,especially primary physicians in rural areas,and provide clinical decision support in clinical practice. | Dezheng Zhang Qi Jia Shibing Yang Xinliang Han Cong Xu Xin Liu Yonghong Xie | 2022 | Computers, Materials & Continua2022，，4： | 4 |
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